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4-异丙基安替比林

4-异丙基安替比林用途

Propyphenazone是一种吡唑啉酮衍生物, 具有消炎、止痛和解热活性的。Propyphenazone为基础的类似物通常作为前药,选择性抑制环氧合酶-2(COX-2)。

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4-异丙基安替比林名称

[ CAS 号 ]:
479-92-5

[ 中文名 ]:
异丙安替比林

[ 英文名 ]:
propyphenazone

[中文别名 ]:

[英文别名 ]:

ANTIBIOTICTPJ-B
causyth
2,3-Dimethyl-1-phenyl-4-isopropylpyrazolone
budirol
PROPYLPHENAZONE
MFCD00053368
arantil P
Isopropylphenazone
Isopropyrine
Propyphenazon

4-异丙基安替比林生物活性

[ 描述 ]:

Propyphenazone是一种吡唑啉酮衍生物, 具有消炎、止痛和解热活性的。Propyphenazone为基础的类似物通常作为前药,选择性抑制环氧合酶-2(COX-2)。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[ 靶点 ]

COX

[参考文献]

[1]. Burdan F, et al. Formation of the knee joint after prenatal propyphenazone (isopropylantipyrine) administration. Cells Tissues Organs. 2002;171(2-3):145-51.

[相关活性小分子]

4-异丙基安替比林物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
319.0±25.0 °C at 760 mmHg

[ 熔点 ]:
102-105°C

[ 分子式 ]:
C₁₄H₁₈N₂O

[ 分子量 ]:
230.305

[ 闪点 ]:
123.8±15.5 °C

[ 精确质量 ]:
230.141907

[ PSA ]:
26.93000

[ LogP ]:
1.74

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.556

[ 储存条件 ]:
Refrigerator

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
水溶性：实际上不溶；水溶解度：2.4 g/l 17 °C；可溶于：乙醚,丙酮,乙醇

4-异丙基安替比林MSDS

4-异丙基安替比林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CD2800000

CHEMICAL NAME :: Antipyrine, 4-isopropyl-

CAS REGISTRY NUMBER :: 479-92-5

BEILSTEIN REFERENCE NO. :: 0204533

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C14-H18-N2-O

MOLECULAR WEIGHT :: 230.34

WISWESSER LINE NOTATION :: T5NNVJ A1 BR& DY1&1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,601,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,401,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 295 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 122,434,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 61,205,1937

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 61,205,1937

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 84,351,1954

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4-异丙基安替比林安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
CD2800000

[ 海关编码 ]:
2933110000

4-异丙基安替比林合成路线

4-异丙基安替比林上下游产品

4-异丙基安替比林上游产品

4-异丙基安替比林下游产品

4-异丙基安替比林海关

[ 海关编码 ]: 2933199090

[ 中文概述 ]:
2933199090. 其他结构上有非稠合吡唑环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-异丙基安替比林文献

Development of a multicommuted flow-through optosensor for the determination of a ternary pharmaceutical mixture.

J. Pharm. Biomed. Anal. 43(2) , 515-21, (2007)

The combination of multicommutation and flow-through multioptosensing is presented in this work as a powerful strategy for the routine analysis of active principles in pharmaceuticals. By coupling met...

Green chromatography separation of analytes of greatly differing properties using a polyethylene glycol stationary phase and a low-toxic water-based mobile phase.

Anal. Bioanal. Chem 405(18) , 6105-15, (2013)

A simple, rapid, and environmentally friendly HPLC method was developed and validated for the separation of four compounds (4-aminophenol, caffeine, paracetamol, and propyphenazone) with different che...

VUV photon-induced ionization/dissociation of antipyrine and propyphenazone: mass spectrometric and theoretical insights.

J. Mass Spectrom. 45(7) , 734-9, (2010)

Two analgesic and anti-inflammatory drugs, antipyrine and propyphenazone, were investigated with infrared laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometr...

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