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5α-胆甾烷

5α-胆甾烷用途

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5α-胆甾烷名称

[ CAS 号 ]:
481-21-0

[ 中文名 ]:
5alpha-胆甾烷

[ 英文名 ]:
(5a)-Cholestane

[中文别名 ]:

[英文别名 ]:

EINECS 207-562-8
(5a)-Cholestane
5α-Cholestane
MFCD00066412
Cholestane, (5α)-
28,29,30-TRINORLANOSTANE
5α-Cholestane (8CI)
5ALPHA-CHOLESTANE
(5α)-Cholestane

5α-胆甾烷物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
440.9±12.0 °C at 760 mmHg

[ 熔点 ]:
78-80 °C

[ 分子式 ]:
C₂₇H₄₈

[ 分子量 ]:
372.670

[ 闪点 ]:
210.3±13.1 °C

[ 精确质量 ]:
372.375610

[ LogP ]:
12.26

[ 外观性状 ]:
灰白色粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.492

[ 储存条件 ]:
room temp

5α-胆甾烷MSDS

5α-胆甾烷安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H319-H331-H336-H351-H361d-H372

[ 警示性声明 ]:
P261-P281-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S24/25-S36/37

[ 危险品运输编码 ]:
UN 1888 6.1/PG 3

[ WGK德国 ]:
3

5α-胆甾烷合成路线

5α-胆甾烷上下游产品

5α-胆甾烷上游产品

5α-胆甾烷下游产品

5α-胆甾烷制备

1.制法：

于装有搅拌器、温度计、通风导管、回流冷凝器(装氯化钙干燥管)的反应瓶中，加入无水乙醚250mL，冷却至-10～-15℃，慢慢通入氯化氢体约45min。而后于-15℃加入胆甾烷酮(2)10g(0.0216mol)。再将反应混合物冷却至-20℃，于2～3minn内加入12.3g(0.19mol)活泼锌^①。慢慢升温至-5℃，于-5～0℃搅拌反应2h。再冷却至-15℃，慢慢将反应物倒入130g碎冰中，充分搅拌。分出有机层，水层用乙醚提取。合并乙醚溶液，用饱和氯化钠洗涤，无水硫酸钠干燥。蒸出乙醚，得无色液体，冷后固化。将固体物溶于30～40mL正己烷，过硅胶柱，用正己烷洗脱。减压蒸出正己烷，得8～8.2g胆甾烷(1)，收率82%～84%。用乙醇-乙醚重结晶，得片状结晶7.3-7.5g，mp78～79℃。注：①活泼锌可按如下方法制备：将通过300目筛孔的16g锌粉用100mL2%的盐酸浸泡约4min，至锌粉表面发亮。倾去稀盐酸，用蒸馏水洗涤4次。抽滤，充分水洗，而后依次用乙醇、丙酮、乙醚洗涤。而后于85～90℃真空干燥，得13～14g活泼锌，立即用于反应。

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5α-胆甾烷文献

Determination of Milk Fat Adulteration with Vegetable Oils and Animal Fats by Gas Chromatographic Analysis.

J. Food Sci. 80 , C1945-51, (2015)

This study assessed the potential application of gas chromatography (GC) in detecting milk fat (MF) adulteration with vegetable oils and animal fats and of characterizing samples by fat source. One hu...

Accelerated separation of GC-amenable lipid classes in plant oils by countercurrent chromatography in the co-current mode.

Anal. Bioanal. Chem 407 , 9019-28, (2015)

Triacylglycerols represent the major part (>90%) in most plant oils and have to be eliminated, when the minor compounds such as phytosterols or tocopherols should be analyzed. Here, we used an all liq...

Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters.

J. Transl. Med. 13 , 278, (2015)

Berberine (BBR), as a new medicine for hyperlipidemia, can reduce the blood lipids in patients. Mechanistic studies have shown that BBR activates the extracellular-signal regulated kinase pathway by s...

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