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((1R,9aR)-八氢-1H-喹嗪-1-基)甲醇

((1R,9aR)-八氢-1H-喹嗪-1-基)甲醇用途

(-)-Lupinine是一种喹唑啉生物碱。

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((1R,9aR)-八氢-1H-喹嗪-1-基)甲醇名称

[ CAS 号 ]:
486-70-4

[ 中文名 ]:
羽扇豆宁

[ 英文名 ]:
NSC 21723

[中文别名 ]:

[英文别名 ]:

LUPININE
EINECS 207-638-0
MFCD00213431
(-)-LUPININE
OCTAHYDRO-1H-QUINOLIZIN-1-METHANOL
((1R,9aR)-Octahydro-1H-quinolizin-1-yl)methanol
LUPININ

((1R,9aR)-八氢-1H-喹嗪-1-基)甲醇生物活性

[ 描述 ]:

(-)-Lupinine是一种喹唑啉生物碱。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Stephen G Davies, et al. An efficient asymmetric synthesis of (-)-lupinine. Chem Commun (Camb). 2014 Aug 7;50(61):8309-11.

((1R,9aR)-八氢-1H-喹嗪-1-基)甲醇物理化学性质

[ 密度 ]:
1.04 g/cm3

[ 沸点 ]:
160-164°C 4mm

[ 熔点 ]:
62-65°C

[ 分子式 ]:
C₁₀H₁₉NO

[ 分子量 ]:
169.26

[ 闪点 ]:
160-164°C/4mm

[ 精确质量 ]:
169.14700

[ PSA ]:
23.47000

[ LogP ]:
1.18110

[ 蒸汽压 ]:
0.000928mmHg at 25°C

[ 折射率 ]:
1.525

[ 储存条件 ]:
2-8°C，干燥

((1R,9aR)-八氢-1H-喹嗪-1-基)甲醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OK5802000

CHEMICAL NAME :: Lupinine

CAS REGISTRY NUMBER :: 486-70-4

BEILSTEIN REFERENCE NO. :: 0080447

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H19-N-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),26,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),26,1946

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),26,1946

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAGRAC Journal of Agricultural Research (Washington, DC). (Washington, DC) V.1-78, 1913-49. Discontinued. Volume(issue)/page/year: 32,51,1926

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((1R,9aR)-八氢-1H-喹嗪-1-基)甲醇安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S22-S36/37

[ 危险品运输编码 ]:
1544

[ RTECS号 ]:
OK5802000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1