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二烯烟碱

二烯烟碱用途

β-烟酸是尼古丁的代谢产物。β-烟酸是从烟草植株的叶子和香烟烟雾冷凝液中分离出来的一种次要烟草生物碱[1]。

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二烯烟碱名称

[ CAS 号 ]:
487-19-4

[ 中文名 ]:
二烯烟碱

[ 英文名 ]:
3-(1-Methyl-1H-pyrrol-2-yl)pyridine

[中文别名 ]:

[英文别名 ]:

Pyridine, 3-(1-methylpyrrol-2-yl)-
Pyridine, 3- (1-methyl-1H-pyrrol-2-yl)-
Pyridine, 3-(1-methyl-1H-pyrrol-2-yl)-
3-(1-methylpyrrol-2-yl)pyridine
Pyridine, 3- (1-methylpyrrol-2-yl)-

二烯烟碱生物活性

[ 描述 ]:

β-烟酸是尼古丁的代谢产物。β-烟酸是从烟草植株的叶子和香烟烟雾冷凝液中分离出来的一种次要烟草生物碱[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Xiaochen Wei, et al. An Improved Synthesis of β-Nicotyrine from the Dehydrogenation of Nicotine: Comparison of Conventional and Microwave-Assisted Reactions. Synthetic Communications. 2003. Volume 33, Issue 19.

二烯烟碱物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
282.8±15.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀H₁₀N₂

[ 分子量 ]:
158.200

[ 闪点 ]:
124.8±20.4 °C

[ 精确质量 ]:
158.084396

[ PSA ]:
17.82000

[ LogP ]:
1.80

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.581

二烯烟碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT6130000

CHEMICAL NAME :: Pyridine, 3-(1-methyl-2-pyrrolyl)-

CAS REGISTRY NUMBER :: 487-19-4

BEILSTEIN REFERENCE NO. :: 0121347

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H10-N2

MOLECULAR WEIGHT :: 158.22

WISWESSER LINE NOTATION :: T6NJ C- BT5NJ A1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4065561

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 575 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4065561

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 191 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 65,366,1982