吲哚基 β-D-葡萄糖苷

吲哚基 β-D-葡萄糖苷用途

Indian(吲哚氧基-β-D-葡萄糖苷)是吲哚氧基的一种糖苷,是染料二甘醇和靛玉红的前体。Indican有一种主要的代谢物,硫酸吲哚氧基(IS)。IS是一种尿毒症毒素,是有机阴离子转运体(OAT)1、OAT 3和多药耐药相关蛋白(MRP)4[1][2]的底物/抑制剂。

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吲哚基 β-D-葡萄糖苷名称

[ CAS 号 ]:
487-60-5

[ 中文名 ]:
3-吲哚基-beta-D-吡喃葡萄糖苷

[ 英文名 ]:
Indican

[中文别名 ]:

[英文别名 ]:

Indikan
Plant indican
Indican
Indole, 3- (β-D-glucopyranosyloxy)-
3-Indolyl-b-D-glucopyranoside
3-Indole-D-glucoside Hydrate
Indoxyl-D-glucoside Hydrate
Indoxyl β-D-glucoside
1H-Indol-3-yl β-D-glucopyranoside
1H-Indol-3-yl β-glucopyranoside

吲哚基 β-D-葡萄糖苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体内研究]

(吲哚氧基-β-D-葡萄糖苷；口头的；20,40mg/kg；单剂量)通过主要代谢物IS抑制多种阴离子转运体(包括OAT 1、OAT 3和MRP 4)增加MTX的全身暴露和MRT[1]。动物模型：雄性Spraguee-Dawley大鼠,体重330-400g[1]剂量：20,40mg/kg给药：口服结果：增加甲氨蝶呤(MTX)的全身暴露和多药耐药相关蛋白(MRP)；5.0毫克/千克)。

[参考文献]

[1]. Shiuan-Pey Lin, et al. Transporter-mediated interaction of indican and methotrexate in rats. J Food Drug Anal. 2018 Apr;26(2S):S133-S140.

[2]. Yu-Chi Hou, et al. Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-beta-D-glucoside (indican) in rats. Toxicon. 2008 Sep 1;52(3):440-4.

吲哚基 β-D-葡萄糖苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
606.7±55.0 °C at 760 mmHg

[ 熔点 ]:
57-58ºC

[ 分子式 ]:
C₁₄H₁₇NO₆

[ 分子量 ]:
295.288

[ 闪点 ]:
320.7±31.5 °C

[ 精确质量 ]:
295.105591

[ PSA ]:
115.17000

[ LogP ]:
-0.75

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.715

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 0.1 M at 20 °C, clear to slightly hazy, colorless to faint yellow-green

吲哚基 β-D-葡萄糖苷MSDS

详细MSDS(安全技术说明书)

吲哚基 β-D-葡萄糖苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

吲哚基 β-D-葡萄糖苷上下游产品

吲哚基 β-D-葡萄糖苷上游产品

吲哚基 β-D-葡萄糖苷下游产品

吲哚基 β-D-葡萄糖苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吲哚基 β-D-葡萄糖苷文献

A modified m-CP medium for enumerating Clostridium perfringens from water samples.

Can. J. Microbiol. 34 , 78, (1988)

Medium m-CP, designed for the isolation of Clostridium perfringens from water samples, contains indoxyl beta-D-glucoside, an expensive chemical that is present at a high concentration in this medium. ...

[Determination of indican in Polygonum tinctorium ait. in various growth periods].

Zhong Yao Tong Bao 13(11) , 11-3, 61-2, (1988)

Distribution, diversity, and seasonality of waterborne salmonellae in a rural watershed.

Appl. Environ. Microbiol. 75(5) , 1248-55, (2009)

Salmonella outbreaks from contaminated water and nonanimal foods (e.g., produce) are increasingly reported. To address the environment as a potential source of pathogenic Salmonella, we investigated l...

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