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2,4,6-三羟基苯甲醛

2,4,6-三羟基苯甲醛用途

2,4,6-三羟基苯甲醛是一种口服活性NF-ĸB抑制剂。2,4,6-三羟基苯甲醛具有抗肿瘤活性、抗癌细胞增殖活性和抗肥胖活性[1][2][3]。

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2,4,6-三羟基苯甲醛名称

[ CAS 号 ]:
487-70-7

[ 中文名 ]:
间苯三酚甲醛

[ 英文名 ]:
2,4,6-Trihydroxybenzaldehyde

[中文别名 ]:

2,4,6-三羟基苯甲醛

[英文别名 ]:

EINECS 207-663-7
MFCD00003329
Phloroglucinolcarboxaldehyde
Benzaldehyde, 2,4,6-trihydroxy-
2,4,6-Trihydroxybenzaldehyde

2,4,6-三羟基苯甲醛生物活性

[ 描述 ]:

2,4,6-三羟基苯甲醛是一种口服活性NF-ĸB抑制剂。2,4,6-三羟基苯甲醛具有抗肿瘤活性、抗癌细胞增殖活性和抗肥胖活性[1][2][3]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[体外研究]

2,4,6-三羟基苯甲醛抑制3T3-L1细胞中的脂肪细胞分化和脂质积累[1]。2,4,6-三羟基苯甲醛下调PPARγ、C/EBPα、SREBP-1c和FAS蛋白表达水平[1]。

[体内研究]

2,4,6-三羟基苯甲醛(口服；5和25 mg/kg,持续13周)可减少HFD引起的体重增加,降低血糖、甘油三酯和总胆固醇的血清水平[1]。

2,4,6-三羟基苯甲醛物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
319.1±22.0 °C at 760 mmHg

[ 熔点 ]:
195 °C (dec.)(lit.)

[ 分子式 ]:
C₇H₆O₄

[ 分子量 ]:
154.120

[ 闪点 ]:
161.0±18.8 °C

[ 精确质量 ]:
154.026611

[ PSA ]:
77.76000

[ LogP ]:
1.37

[ 外观性状 ]:
淡粉红色结晶粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.734

[ 储存条件 ]:
室温

2,4,6-三羟基苯甲醛MSDS

详细MSDS(安全技术说明书)

2,4,6-三羟基苯甲醛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CU8440000

CHEMICAL NAME :: Benzaldehyde, 2,4,6-trihydroxy-

CAS REGISTRY NUMBER :: 487-70-7

BEILSTEIN REFERENCE NO. :: 2254429

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H6-O4

MOLECULAR WEIGHT :: 154.13

WISWESSER LINE NOTATION :: VHR BQ DQ FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year: 34,1196,1940

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2,4,6-三羟基苯甲醛安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P280-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
CU8440000

[ 海关编码 ]:
2912499000

2,4,6-三羟基苯甲醛海关

[ 海关编码 ]: 2912499000

[ 中文概述 ]:
2912499000. 其他醛醚、醛酚及含其他含氧基的醛. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 四聚甲醛报明外观

[ Summary ]:
2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

2,4,6-三羟基苯甲醛文献

Health-Beneficial Phenolic Aldehyde in Antigonon leptopus Tea.

Evid. Based. Complement. Alternat. Med. 2011 , 601249, (2012)

Tea prepared from the aerial parts of Antigonon leptopus is used as a remedy for cold and pain relief in many countries. In this study, A. leptopus tea, prepared from the dried aerial parts, was evalu...

2,4,6-Trihydroxybenzaldehyde, a potential anti-obesity treatment, suppressed adipocyte differentiation in 3T3-L1 cells and fat accumulation induced by high-fat diet in C57BL/6 mice.

Environ. Toxicol. Pharmacol. 39 , 962-8, (2015)

In the present study, 2,4,6-trihydroxybenzaldehyde (THB) was evaluated for inhibitory effects on adipocyte differentiation in 3T3-L1 cells and anti-obesity effects in mice with high-fat diet (HFD)-ind...

A comprehensive investigation of guaiacyl-pyranoanthocyanin synthesis by one-/two-dimensional NMR and UPLC-DAD-ESI-MS(n).

Food Chem. 199 , 902-10, (2016)

In red and rosé wines, the grape anthocyanins are progressively converted to more stable pigments, including phenylpyranoanthocyanins. One-/two-dimensional NMR and UPLC-DAD-ESI-MS(n) measurements were...

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