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山奈素

山奈素用途

Kaempferide是一种O-甲基化黄酮醇,也存在于山柰中。

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山奈素名称

[ CAS 号 ]:
491-54-3

[ 中文名 ]:
山奈素

[ 英文名 ]:
Kaempferide

[中文别名 ]:

[英文别名 ]:

4'-O-Methylkaempferol
Kaempferol 4'-methyl ether
3,5,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one
3,5,7-trihydroxy-4'-methoxyflavone
Kaempferid
Kaempferide
3 5 7-trihydroxy-4'-methoxyflavone
4'-Methoxy-3,5,7-trihydroxyflavone
3,5,7-trihydroxy-4′-methoxyflavone
4'-Methylkaempferol

山奈素生物活性

[ 描述 ]:

Kaempferide是一种O-甲基化黄酮醇,也存在于山柰中。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 其他 >> 雌激素受体/ERR

天然产物 >> 黄酮类化合物

研究领域 >> 其他

[参考文献]

[1]. Otake Y, Walle T. Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. Drug Metab Dispos. 2002 Feb;30(2):103-5.

[2]. Martineti V, Tognarini I, Azzari C et al. Inhibition of in vitro growth and arrest in the G0/G1 phase of HCT8 line human colon cancer cells by kaempferide triglycoside from Dianthus caryophyllus. Phytother Res. 2010 Sep;24(9):1302-8.

[3]. Pahua-Ramos, Maria Elena; Ortiz-Moreno, Alicia; Chamorro-Cevallos, German et al. Hypolipidemic Effect of Avocado (Persea americana Mill) Seed in a Hypercholesterolemic Mouse Model. Plant Foods for Human Nutrition (New York, NY, United States) (2012), 67(1), 10-16.

[4]. Soucek, Pavel; Kondrova, Eliska; Hermanek, Josef et al. New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals. Anti-Cancer Drugs (2011), 22(2), 176-184.

[相关活性小分子]

山奈素物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
543.8±50.0 °C at 760 mmHg

[ 熔点 ]:
156-157ºC(lit.)

[ 分子式 ]:
C₁₆H₁₂O₆

[ 分子量 ]:
300.263

[ 闪点 ]:
207.1±23.6 °C

[ 精确质量 ]:
300.063385

[ PSA ]:
100.13000

[ LogP ]:
2.74

[ 外观性状 ]:
固体;Light orange to Yellow to Green powder to crystal

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.710

[ 储存条件 ]:
2-8°C

山奈素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK6915000

CHEMICAL NAME :: Flavanone, 4'-methoxy-3,5,7-trihydroxy-

CAS REGISTRY NUMBER :: 491-54-3

BEILSTEIN REFERENCE NO. :: 0305378

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-O6

MOLECULAR WEIGHT :: 300.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 5,1489,1977

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山奈素安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
KD4170000

[ 海关编码 ]:
29329990

山奈素合成路线

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山奈素文献

Metabolite profiling of polyphenols in the Tunisian plant Tamarix aphylla (L.) Karst.

J. Pharm. Biomed. Anal. 99 , 97-105, (2014)

In this study, a detailed investigation on the composition of polyphenols of Tamarix aphylla (L.) Karst., consisting of phenolic acids and flavonoids, was carried out. In order to optimize the yield o...

Identification of known chemicals and their metabolites from Alpinia oxyphylla fruit extract in rat plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) with selected reaction monitoring.

J. Pharm. Biomed. Anal. 97 , 166-77, (2014)

Alpinia oxyphylla (Yizhi) capsularfruits are commonly used in traditional medicine. Pharmacological studies have demonstrated that A. oxyphylla capsularfruits have some beneficial roles. Besides volat...

Highly sensitive analysis of flavonoids by zwitterionic microemulsion electrokinetic chromatography coupled with light-emitting diode-induced fluorescence detection.

J. Chromatogr. A. 1358 , 277-84, (2014)

A rapid zwitterionic microemulsion electrokinetic chromatography (ZI-MEEKC) approach coupled with light-emitting-diode-induced fluorescence (LED-IF, 480nm) detection was proposed for the analysis of f...

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山奈素