7-氨基硝基安定

[ 密度 ]:
1.3g/cm3

[ 沸点 ]:
495.8ºC at 760 mmHg

[ 熔点 ]:
242-244ºC

[ 分子式 ]:
C₁₅H₁₃N₃O

[ 分子量 ]:
251.28300

[ 闪点 ]:
253.6ºC

[ 精确质量 ]:
251.10600

[ PSA ]:
67.48000

[ LogP ]:
2.21310

[ 折射率 ]:
1.683

[ 储存条件 ]:
库房通风低温干燥

CHEMICAL IDENTIFICATION

RTECS NUMBER :

DE9750000

CHEMICAL NAME :

2H-1,4-Benzodiazepin-2-one, 7-amino-1,3-dihydro-5-phenyl-

CAS REGISTRY NUMBER :

4928-02-3

BEILSTEIN REFERENCE NO. :

0535813

LAST UPDATED :

199712

DATA ITEMS CITED :

1

MOLECULAR FORMULA :

C15-H13-N3-O

MOLECULAR WEIGHT :

251.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

300 mg/kg

SEX/DURATION :

female 12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,209,1991

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H332-H319

[ 警示性声明 ]:
P210-P305 + P351 + P338

[ 危害码 (欧洲) ]:
F,Xn

[ 风险声明 (欧洲) ]:
11-20/21/22-36

[ 安全声明 (欧洲) ]:
16-36/37

[ 危险品运输编码 ]:
UN 1648 3 / PGII

详细合成路线

7-氨基硝基安定上游产品

7-氨基硝基安定下游产品

Measurement of benzodiazepines in urine by liquid chromatography-tandem mass spectrometry: confirmation of samples screened by immunoassay.

Ann. Clin. Biochem. 47(Pt 2) , 111-7, (2010)

Liquid chromatography linked to tandem mass spectrometry (LC/MS/MS) provides the ability to identify a range of benzodiazepines in accordance with European Union criteria and is an attractive method f...

A highly sensitive method for the determination of 7-aminonitrazepam, a metabolite of nitrazepam, in human urine using high-performance electrospray liquid chromatography tandem mass spectrometry.

Biomed. Chromatogr. 23(7) , 740-4, (2009)

A highly sensitive method has been developed for the determination of urinary 7-aminonitrazepam (7-ANZP), the major metabolite of nitrazepam, using high-performance electrospray liquid chromatography ...

Determination of nitrazepam and its main metabolites in urine by thin-layer chromatography and direct densitometry.

J. Chromatogr. A. 339(1) , 163-9, (1985)

A method for the direct quantitative densitometry of nitrazepam and its main metabolites (7-aminonitrazepam, 7-acetamidonitrazepam and 2-amino-5-nitrobenzophenone) in urine was developed. The unchange...

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