橙皮油内酯

橙皮油内酯用途

Auraptene 是最丰富的天然香叶氧基香豆素。Auraptene 主要从芸香科植物中分离出来,如柑橘类水果。 Auraptene 降低基质金属蛋白酶 2 (MMP-2) 以及关键炎症因子,如 IL-6,IL-8 和趋化因子 (C-C 基序) 配体-5 (CCL5)的分泌。

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橙皮油内酯名称

[ CAS 号 ]:
495-02-3

[ 中文名 ]:
橙皮油素

[ 英文名 ]:
Auraptene

[中文别名 ]:

橙皮油内酯

[英文别名 ]:

Auraptene
7-Geranyloxycoumarin
aurapten

橙皮油内酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 代谢酶/蛋白酶 >> MMP

[ 靶点 ]

MMP-2

[参考文献]

[1]. La VD, et al. Anti-inflammatory and wound healing potential of citrus auraptene. J Med Food. 2013 Oct;16(10):961-4.

橙皮油内酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
455.5±45.0 °C at 760 mmHg

[ 熔点 ]:
66 °C

[ 分子式 ]:
C₁₉H₂₂O₃

[ 分子量 ]:
298.376

[ 闪点 ]:
195.4±23.3 °C

[ 精确质量 ]:
298.156891

[ PSA ]:
39.44000

[ LogP ]:
5.69

[ 外观性状 ]:
white to off-white

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.549

[ 储存条件 ]:
?20°C

[ 水溶解性 ]:
DMSO: >20mg/mL

橙皮油内酯MSDS

详细MSDS(安全技术说明书)

橙皮油内酯安全信息

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

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橙皮油内酯文献

Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1α degradation.

Oncotarget 6 , 38127-38, (2015)

Renal cell carcinoma (RCC) progression resulting from the uncontrolled migration and enhanced angiogenesis is an obstacle to effective therapeutic intervention. Tumor metabolism has distinctive featur...

Novel prodrugs for the treatment of colonic diseases based on 5-aminosalicylic acid, 4'-geranyloxyferulic acid, and auraptene: biological activities and analytical assays.

Curr. Drug Deliv. 9(2) , 112-21, (2012)

A pro-drug is a substance administered in a pharmacologically inactive structure that, once administered, is metabolised in vivo into the corresponding active principle. The rationale for the design o...

Development of a quantitative bioassay to assess preventive compounds against inflammation-based carcinogenesis.

Nitric Oxide 25(2) , 183-94, (2011)

Reducing cancer incidence and mortality by use of cancer-chemopreventive agents is an important goal. We have established an in vitro bioassay that is able to screen large numbers of candidate chemica...

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