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3-乙酰脱氧瓜萎镰菌醇

3-乙酰脱氧瓜萎镰菌醇用途

3-Acetyldeoxynivalenol,一种单端孢霉烯霉菌毒素脱氧雪腐镰刀菌烯醇 (DON) 乙酰化衍生物,是血脑屏障 (BBB) 可渗透的真菌毒素。

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3-乙酰脱氧瓜萎镰菌醇名称

[ CAS 号 ]:
50722-38-8

[ 中文名 ]:
3-乙酰脱氧瓜萎镰菌醇

[ 英文名 ]:
Trichothec-9-en-8-one,3-(acetyloxy)-12,13-epoxy-7,15-dihydroxy-, (3a,7a)-

[中文别名 ]:

3-乙酰基脱氧雪腐镰刀菌烯醇

[英文别名 ]:

MFCD00135964
3-acetyldeoxynivalenol

3-乙酰脱氧瓜萎镰菌醇生物活性

[ 描述 ]:

3-Acetyldeoxynivalenol,一种单端孢霉烯霉菌毒素脱氧雪腐镰刀菌烯醇 (DON) 乙酰化衍生物,是血脑屏障 (BBB) 可渗透的真菌毒素。

[ 相关类别 ]:

研究领域 >> 心血管疾病

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Kadota T, et al. Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenolon intestinal transport and IL-8 secretion in the human cell line Caco-2. Toxicol In Vitro. 2013 Sep;27(6):1888-95.

[2]. Behrens M, et al. Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain. PLoS One. 2015 Nov 23;10(11):e0143640.

3-乙酰脱氧瓜萎镰菌醇物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
529.8±50.0 °C at 760 mmHg

[ 熔点 ]:
185.75°C

[ 分子式 ]:
C₁₇H₂₂O₇

[ 分子量 ]:
322.353

[ 闪点 ]:
195.2±23.6 °C

[ 精确质量 ]:
322.141632

[ PSA ]:
96.36000

[ LogP ]:
-0.85

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.598

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

3-乙酰脱氧瓜萎镰菌醇MSDS

详细MSDS(安全技术说明书)

3-乙酰脱氧瓜萎镰菌醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YD0150000

CHEMICAL NAME :: Trichothec-9-en-8-one, 3-(acetyloxy)-7,15-dihydroxy-, (3-alpha,7-alpha)-

CAS REGISTRY NUMBER :: 50722-38-8

LAST UPDATED :: 198910

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H22-O7

MOLECULAR WEIGHT :: 338.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - hypermotility, diarrhea

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960- Volume(issue)/page/year: 15,261,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

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3-乙酰脱氧瓜萎镰菌醇安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H311-H331

[ 警示性声明 ]:
P261-P264-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;F: Flammable;Xn: Harmful;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S45;S36/S37

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
YD0150000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

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3-乙酰脱氧瓜萎镰菌醇文献

Development and validation of a high performance liquid chromatographic-mass spectrometry method for the simultaneous quantification of 10 trichothecenes in ultra-high temperature processed cow milk.

J. Chromatogr. A. 1419 , 37-44, (2015)

An LC-MS/MS (QqQ) method has been developed and validated for simultaneous determination of the following trichothecenes in UHT cow milk: nivalenol (NIV), deoxynivalenol (DON), deepoxy-deoxynivalenol ...

Preliminary estimation of deoxynivalenol excretion through a 24 h pilot study.

Toxins (Basel.) 7 , 705-18, (2015)

A duplicate diet study was designed to explore the occurrence of 15 Fusarium mycotoxins in the 24 h-diet consumed by one volunteer as well as the levels of mycotoxins in his 24 h-collected urine. The ...

Innate Immune Sensing of Fusarium culmorum by Mouse Dendritic Cells.

J. Toxicol. Environ. Health A 78 , 871-85, (2015)

Chronic inhalation of grain dust is associated with asthma and chronic bronchitis in grain worker populations. Exposure to fungal particles was postulated to be an important etiologic agent of these p...

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