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毒毛旋花苷K

毒毛旋花苷K用途

Cymarin是一种强心苷,能有效地抑制由孢粉毒素(PTX)诱导的K+释放(IC50=0.42μM)[1]。

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毒毛旋花苷K名称

[ CAS 号 ]:
508-77-0

[ 中文名 ]:
罗布麻苷

[ 英文名 ]:
Cymarin

[中文别名 ]:

[英文别名 ]:

KOMBETIN
K-STROPHANTHIN-A
CIMARIN
STROPHANTHIN K
MFCD00003669
EINECS 208-087-9
alvonalmr
K STROPHANTHIN

毒毛旋花苷K生物活性

[ 描述 ]:

Cymarin是一种强心苷,能有效地抑制由孢粉毒素(PTX)诱导的K+释放(IC50=0.42μM)[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Ozaki H, et al. Interaction of palytoxin and cardiac glycosides on erythrocyte membrane and (Na+ + K+) ATPase. Eur J Biochem. 1985;152(2):475-480.

毒毛旋花苷K物理化学性质

[ 密度 ]:
1.31 g/cm3

[ 沸点 ]:
722.1ºCat 760 mmHg

[ 熔点 ]:
148ºC

[ 分子式 ]:
C₃₀H₄₄O₉

[ 分子量 ]:
548.66

[ 闪点 ]:
232.7ºC

[ 精确质量 ]:
548.29900

[ PSA ]:
131.75000

[ LogP ]:
2.43330

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.589

[ 储存条件 ]:
2-8°C，密封，干燥，避光，惰性气体

毒毛旋花苷KMSDS

详细MSDS(安全技术说明书)

毒毛旋花苷K毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ5600000

CHEMICAL NAME :: Cymarin

CAS REGISTRY NUMBER :: 508-77-0

BEILSTEIN REFERENCE NO. :: 0101370

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C30-H44-O9

MOLECULAR WEIGHT :: 548.74

WISWESSER LINE NOTATION :: L E5 B666TJ AVH E1 IQ MQ F- DT5OV EHJ& OO- FT6OTJ B1 CQ DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 155,165,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 155,165,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2800 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,908,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,908,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 95 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 74,223,1942

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 110 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 98,297,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 110 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 148,471,1964 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,189,1963 TOXICOLOGY REVIEW CHIMAD Chimia. (Postfach 2027, CH-4001 Basel, Switzerland) V.1- 1947- Volume(issue)/page/year: 5,93,1951

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毒毛旋花苷K安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H331-H373

[ 警示性声明 ]:
P261-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R23/25

[ 安全声明 (欧洲) ]:
45-36/37/39-36/37-28-26

[ 危险品运输编码 ]:
UN 3462 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
GZ5600000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

毒毛旋花苷K文献

Increased in vivo synthesis of retinal Na pump isoforms after pre-treatment with citrate buffer.

Prog. Clin. Biol. Res. 268B , 143-7, (1988)

[Determination of zimarin in urine].

Sud. Med. Ekspert. 32(2) , 35-6, (1989)

Private technique of extraction isolation and purification, chromatographic detection and photometric determination of zimarin in urine is suggested. Detection limit is 0.01 mg, determination limit is...

[Validity of cardioactive glycosides].

Minerva Anestesiol. 58(10) , 639-45, (1992)

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