5-DIMETHYLAMINO-6-PROPYL-5H-INDENO(5,6-d)-1,3-DIOXOLE HYDROCHLORIDE
名称
[ CAS 号 ]:
51003-81-7
[ 英文名 ]:
5-DIMETHYLAMINO-6-PROPYL-5H-INDENO(5,6-d)-1,3-DIOXOLE HYDROCHLORIDE
[英文别名 ]:
- Cyclohexane,1-methylene-2-propyl
- 2-n-propyl-1-methylenecyclohexane
物理化学性质
[ 分子式 ]:
C15H20ClNO2
[ 分子量 ]:
281.77800
[ 精确质量 ]:
281.11800
[ PSA ]:
21.70000
[ LogP ]:
4.01710
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NK8927000
- CHEMICAL NAME :
- 5H-Indeno(5,6-d)-1,3-dioxole, 5-dimethylamino-6-propyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 51003-81-7
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C15-H19-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 281.81
- WISWESSER LINE NOTATION :
- T C565 DO FO EH JHJ JN1&1 K3 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 175 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Gastrointestinal - decreased motility or constipation
- REFERENCE :
- RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 26,85,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 185 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Gastrointestinal - decreased motility or constipation
- REFERENCE :
- RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 26,85,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Gastrointestinal - decreased motility or constipation
- REFERENCE :
- RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 26,85,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1470 mg/kg/4W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
- REFERENCE :
- RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 26,85,1979
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