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溴甲菲啶

溴甲菲啶用途

溴化二钠是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

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溴甲菲啶名称

[ CAS 号 ]:
518-67-2

[ 中文名 ]:
3,8-二氨基-5-甲基-6-苯基溴化菲啶盐

[ 英文名 ]:
Dimidium bromide

[中文别名 ]:

[英文别名 ]:

Dimidiniumbromide
Phenanthridinium1553
DiMidiuM BroMide
DIMIDIUM BROMIDE 1/2 H2O
MFCD00011757
Phenanthridiniumcompound1553
6c46
EINECS 208-256-7
TRYPADINE

溴甲菲啶生物活性

[ 描述 ]:

溴化二钠是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

溴甲菲啶物理化学性质

[ 熔点 ]:
243-248 °C(lit.)

[ 分子式 ]:
C₂₀H₁₈BrN₃

[ 分子量 ]:
380.281

[ 精确质量 ]:
379.068390

[ PSA ]:
55.92000

[ LogP ]:
1.81530

[ 外观性状 ]:
固体;Orange to Brown to Dark purple powder to crystal

[ 储存条件 ]:
2-8°C

溴甲菲啶MSDS

溴甲菲啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SF7960500

CHEMICAL NAME :: Phenanthridinium, 3,8-diamino-5-methyl-6-phenyl-, bromide

CAS REGISTRY NUMBER :: 518-67-2

LAST UPDATED :: 199512

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H18-N3.Br

MOLECULAR WEIGHT :: 380.32

WISWESSER LINE NOTATION :: T B666 HKJ EZ H1 IR& LZ &E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 61 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 1,65,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 5,261,1950 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 10 mg/kg/5D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 1,65,1946 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6236 No. of Facilities: 34 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 67 (estimated) No. of Female Employees: 34 (estimated)

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溴甲菲啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
SF7960500

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933990090

溴甲菲啶合成路线

溴甲菲啶上下游产品

溴甲菲啶上游产品

溴甲菲啶下游产品

溴甲菲啶海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

溴甲菲啶文献

A comparison of the base-pair specificities of three phenanthridine drugs using solution spectroscopy.

Int. J. Biochem. 14 , 493, (1982)

1. The absorption spectrum of three phenanthridine drugs (ethidium, dimidium and prothidium bromide) bound to natural DNAs of differing G-C content were obtained using a novel mixing scheme and analys...

[Effect of some DNA-intercalators and antioxidants on the phagosome- lysosome fusion and F-actin content in murine peritoneal macrophages].

Tsitologiia 40(6) , 585-90, (1998)

Effect of DNA-intercalators ethidium bromide (EB, 0.005 and 0.015 mM) and dimidium bromide (DB, 0.005 and 0.010 mM) and antioxidative compounds acetylsalicylic acid (ASA, 0.05 and 0.50 mM) and beta-ca...

[The toxicity of sanguinarine compared to a number of other DNA-tropic compounds for ethidium bromide-sensitive and -resistant transformed murine fibroblasts in culture].

Tsitologiia 31(11) , 1363-8, (1989)

A natural DNA-intercalator plant benzo-c-phenanthridine alkaloid sanguinarine is more toxic for mouse transformed fibroblast L-cells in culture than synthetic DNA-intercalator ethidium bromide (EtB) a...

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