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萘普生杂质A

萘普生杂质A名称

[ CAS 号 ]:
52079-10-4

[ 中文名 ]:
(S)-2-(6-羟基-2-萘)丙酸

[ 英文名 ]:
O-Desmethylnaproxen

[中文别名 ]:

[英文别名 ]:

萘普生杂质A物理化学性质

[ 沸点 ]:
444.1ºC at 760mmHg

[ 熔点 ]:
182-183ºC

[ 分子式 ]:
C13H12O3

[ 分子量 ]:
216.23300

[ 闪点 ]:
236.5ºC

[ 精确质量 ]:
216.07900

[ PSA ]:
57.53000

[ LogP ]:
2.73350

[ 外观性状 ]:
white

[ 储存条件 ]:
2-8°C

萘普生杂质A安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H317-H400

[ 警示性声明 ]:
P273-P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
22-43-50/53

[ 安全声明 (欧洲) ]:
36/37-60-61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ 海关编码 ]:
2918199090

萘普生杂质A合成路线

萘普生杂质A上下游产品

萘普生杂质A海关

[ 海关编码 ]: 2918199090

[ 中文概述 ]:
HS: 2918199090. 其他含醇基但不含其他含氧基羧酸(包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

萘普生杂质A文献

The pharmacokinetic profile of naproxen suppository in man.

Int. J. Clin. Pharmacol. Ther. Toxicol. 26(4) , 190-3, (1988)

After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2....

Sulphation of o-desmethylnaproxen and related compounds by human cytosolic sulfotransferases.

Br. J. Clin. Pharmacol. 60(6) , 632-40, (2005)

Naproxen is a nonsteroidal anti-inflammatory drug widely used as an analgesic and anti-inflammatory agent. The conjugated forms of naproxen and O-DMN, its demethylated metabolite, account for 66-92% o...

High-performance liquid chromatographic determination of 6-desmethylnaproxen sulfate in human plasma.

J. Chromatogr. A. 383(2) , 449-55, (1986)


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