萘普生杂质A
萘普生杂质A名称
[ CAS 号 ]:
52079-10-4
[ 中文名 ]:
(S)-2-(6-羟基-2-萘)丙酸
[ 英文名 ]:
O-Desmethylnaproxen
[中文别名 ]:
[英文别名 ]:
- (2S)-2-(6-hydroxynaphthalen-2-yl)propanoic acid
萘普生杂质A物理化学性质
[ 沸点 ]:
444.1ºC at 760mmHg
[ 熔点 ]:
182-183ºC
[ 分子式 ]:
C13H12O3
[ 分子量 ]:
216.23300
[ 闪点 ]:
236.5ºC
[ 精确质量 ]:
216.07900
[ PSA ]:
57.53000
[ LogP ]:
2.73350
[ 外观性状 ]:
white
[ 储存条件 ]:
2-8°C
萘普生杂质A安全信息
[ 符号 ]:
GHS07, GHS09
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302-H317-H400
[ 警示性声明 ]:
P273-P280
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn,N
[ 风险声明 (欧洲) ]:
22-43-50/53
[ 安全声明 (欧洲) ]:
36/37-60-61
[ 危险品运输编码 ]:
UN 3077 9/PG 3
[ WGK德国 ]:
3
[ 海关编码 ]:
2918199090
萘普生杂质A合成路线
萘普生杂质A上下游产品
萘普生杂质A上游产品
萘普生杂质A下游产品
萘普生杂质A海关
[ 海关编码 ]: 2918199090
[ 中文概述 ]:
HS: 2918199090. 其他含醇基但不含其他含氧基羧酸(包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
萘普生杂质A文献
Int. J. Clin. Pharmacol. Ther. Toxicol. 26(4) , 190-3, (1988)
After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2....
Sulphation of o-desmethylnaproxen and related compounds by human cytosolic sulfotransferases.Br. J. Clin. Pharmacol. 60(6) , 632-40, (2005)
Naproxen is a nonsteroidal anti-inflammatory drug widely used as an analgesic and anti-inflammatory agent. The conjugated forms of naproxen and O-DMN, its demethylated metabolite, account for 66-92% o...
High-performance liquid chromatographic determination of 6-desmethylnaproxen sulfate in human plasma.J. Chromatogr. A. 383(2) , 449-55, (1986)
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