Lobaric acid

Lobaric acid用途

Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 μM for the human recombinant enzyme) and production of 12(S)-HETE (Item No. 34570) by 12(S)-lipoxygenase (IC50 = 28.5 μM). In vivo, lobaric acid (250 μM) decreases lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).

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Lobaric acid名称

[ CAS 号 ]:
522-53-2

[ 英文名 ]:
Lobaric acid

[英文别名 ]:

Usnetic acid
Lobaric acid

Lobaric acid物理化学性质

[ 密度 ]:
1.265g/cm3

[ 沸点 ]:
667.9ºC at 760mmHg

[ 分子式 ]:
C₂₅H₂₈O₈

[ 分子量 ]:
456.48500

[ 闪点 ]:
225.7ºC

[ 精确质量 ]:
456.17800

[ PSA ]:
119.36000

[ LogP ]:
5.52950

[ 折射率 ]:
1.579

[ 储存条件 ]:
-20°C，密闭，干燥

Lobaric acid

Lobaric acid用途

Lobaric acid名称

Lobaric acid物理化学性质

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