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甲苯咪唑杂质A

甲苯咪唑杂质A用途

Mebendazole-amine 是 Mebendazole 的代谢产物。Mebendazole 是广谱苯并咪唑抗蠕虫药。

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甲苯咪唑杂质A名称

[ CAS 号 ]:
52329-60-9

[ 中文名 ]:
(2-氨基-1H-苯并[d]咪唑-5基)-苯甲酮

[ 英文名 ]:
Mebendazole-amine

[中文别名 ]:

甲苯咪唑杂质A

[英文别名 ]:

Ketone,2-amino-5-benzimidazolyl phenyl
G-1029
Benzimidazole,2-amino-5-benzoyl
2-Amino-5-benzoyl-1H-benzimidazole
2-Amino-5-benzoylbenzimidazole
KETONE,2-AMINO-6-BENZIMIDAZOLYL PHENYL

甲苯咪唑杂质A生物活性

[ 描述 ]:

Mebendazole-amine 是 Mebendazole 的代谢产物。Mebendazole 是广谱苯并咪唑抗蠕虫药。

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Majewsky M, et al. Systematic identification of suspected anthelmintic benzimidazole metabolites using LC-MS/MS. J Pharm Biomed Anal. 2018;151:151-158.

[2]. Pantziarka P, et al. Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent. Ecancermedicalscience. 2014;8:443. Published 2014 Jul 10.

甲苯咪唑杂质A物理化学性质

[ 密度 ]:
1.351g/cm3

[ 沸点 ]:
504.5ºC at 760 mmHg

[ 熔点 ]:
176-185°C

[ 分子式 ]:
C₁₄H₁₁N₃O

[ 分子量 ]:
237.25700

[ 闪点 ]:
258.9ºC

[ 精确质量 ]:
237.09000

[ PSA ]:
72.50000

[ LogP ]:
2.30620

[ 折射率 ]:
1.738

[ 储存条件 ]:
-20°C Freezer, Under Inert Atmosphere

甲苯咪唑杂质AMSDS

详细MSDS(安全技术说明书)

甲苯咪唑杂质A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OB1085000

CHEMICAL NAME :: Ketone, 2-amino-6-benzimidazolyl phenyl

CAS REGISTRY NUMBER :: 52329-60-9

LAST UPDATED :: 199307

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H11-N3-O

MOLECULAR WEIGHT :: 237.28

WISWESSER LINE NOTATION :: T56 BM DNJ CZ GVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPPBAB Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932- Volume(issue)/page/year: 48(4),29,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 257 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPPBAB Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932- Volume(issue)/page/year: 48(4),29,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 755 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976

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甲苯咪唑杂质A安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
OB1085000

[ 海关编码 ]:
2933990090

甲苯咪唑杂质A上下游产品

甲苯咪唑杂质A上游产品

甲苯咪唑杂质A下游产品

甲苯咪唑杂质A海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%