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盐酸联苯胺

盐酸联苯胺用途

【用途一】
定量测定硫酸盐和多种金属试剂，测定血液，检验氰化物，萃取稀有金属元素钍和铀。高纯级在生物学实验中用于诱发试验动物的乳腺癌。

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盐酸联苯胺名称

[ CAS 号 ]:
531-85-1

[ 中文名 ]:
联苯胺二盐酸盐

[ 英文名 ]:
Benzidine dihydrochloride

[中文别名 ]:

[英文别名 ]:

Benzidine Dihydrochloride
EINECS 208-519-6
4-(4-aminophenyl)aniline,dihydrochloride
MFCD00040389

盐酸联苯胺物理化学性质

[ 密度 ]:
1.156g/cm3

[ 沸点 ]:
>402ºC

[ 熔点 ]:
≥300 °C

[ 分子式 ]:
C₁₂H₁₄Cl₂N₂

[ 分子量 ]:
257.15900

[ 闪点 ]:
203.5ºC

[ 精确质量 ]:
256.05300

[ PSA ]:
52.04000

[ LogP ]:
5.28440

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
0.1-0.5 g/100 mL at 23.5 ºC

盐酸联苯胺MSDS

盐酸联苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD0600000

CHEMICAL NAME :: Benzidine, dihydrochloride

CAS REGISTRY NUMBER :: 531-85-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 31

MOLECULAR FORMULA :: C12-H12-N2.2Cl-H

MOLECULAR WEIGHT :: 257.18

WISWESSER LINE NOTATION :: ZR DR DZ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 62 mg/kg/4W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3360 mg/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 75 mg/kg/3Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg/84W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Endocrine - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5040 mg/kg/60W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8064 mg/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1680 mg/kg/40W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13440 mg/kg/1Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 94,449,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83072 No. of Facilities: 64 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 598 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83072 No. of Facilities: 103 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2987 (estimated) No. of Female Employees: 2464 (estimated)

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盐酸联苯胺安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H350-H410

[ 警示性声明 ]:
P201-P273-P308 + P313-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R45;R22;R50/53

[ 安全声明 (欧洲) ]:
S53-S45-S60-S61

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
DD0600000

[ 海关编码 ]:
2921590090

盐酸联苯胺合成路线

盐酸联苯胺上下游产品

盐酸联苯胺上游产品

盐酸联苯胺下游产品

盐酸联苯胺海关

[ 海关编码 ]: 2921590090

[ 中文概述 ]:
2921590090. 其他芳香多胺及衍生物及它们的盐. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

盐酸联苯胺文献

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The excretory/secretory (ES) proteins of schistosomes play important roles in modulating host immune systems and are regarded as potential vaccine candidates and drug targets. Protein disulfide isomer...

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Autophagy is required for hematopoietic stem cell multilineage differentiation, but the underlying mechanism is unknown. Using a conditional mouse model and human leukemia cells, we uncovered a mechan...

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