扁桃腈

【用途一】
有机中间体。

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
282.7±20.0 °C at 760 mmHg

[ 熔点 ]:
-10 °C

[ 分子式 ]:
C₈H₇NO

[ 分子量 ]:
133.147

[ 闪点 ]:
97.2±0.0 °C

[ 精确质量 ]:
133.052765

[ PSA ]:
44.02000

[ LogP ]:
0.83

[ 外观性状 ]:
黄色至棕色液体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.568

[ 储存条件 ]:
库房通风低温干燥,与氧化剂,酸类,食品分开储运

[ 稳定性 ]:
Stable, but moisture sensitive. Combustible. Incompatible with strong oxidizing agents.

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

OO8400000

CHEMICAL NAME :

Mandelonitrile

CAS REGISTRY NUMBER :

532-28-5

BEILSTEIN REFERENCE NO. :

2207122

LAST UPDATED :

199701

DATA ITEMS CITED :

7

MOLECULAR FORMULA :

C8-H7-N-O

MOLECULAR WEIGHT :

133.16

WISWESSER LINE NOTATION :

QYR&CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

23 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5600 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

6 mg/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Amphibian - frog

DOSE/DURATION :

600 ug/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Lungs, Thorax, or Respiration - respiratory stimulation

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

DOSE/DURATION :

225 nmol/plate

REFERENCE :

SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 198,625,1977

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H318

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S22-S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3276 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
OO8400000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2926909090

详细合成路线

由苯甲醛与氰化钠加成而得。将氰化钠溶于水，搅拌冷却，在-5～5℃滴加苯甲醛，加完后再加入盐酸，温度保持在10℃左右，静置。分取油层，水洗，得成品。

[ 海关编码 ]: 2926909090

[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Protein engineering of a nitrilase from Burkholderia cenocepacia J2315 for efficient and enantioselective production of (R)-o-chloromandelic acid.

Appl. Environ. Microbiol. 81 , 8469-77, (2015)

The nitrilase-mediated pathway has significant advantages in the production of optically pure aromatic α-hydroxy carboxylic acids. However, low enantioselectivity and activity are observed on hydrolyz...

Metabolites of amygdalin under simulated human digestive fluids.

Int. J. Food Sci. Nutr. 61(8) , 770-9, (2010)

In the present study, degradation of amygdalin in the human digestive fluids and absorption of its metabolites by the human small intestine were evaluated by simulating a gastrointestinal digestion mo...

Hydroxynitrile lyase catalysis in ionic liquid-containing systems.

Biotechnol. Lett. 27(18) , 1387-90, (2005)

The cleavage of mandelonitrile catalysed by hydroxynitrile lyases (HNL) from Prunus amygdalus (PaHNL) and Manihot esculenta (MeHNL) proceeded more rapidly in monophasic aqueous media containing 1-prop...

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：扁桃腈

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥1199.0/500g ￥99.0/25g ￥299.0/100g ￥需询单/1g

联系人：阿拉丁

产品详情：扁桃腈

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