Pyrithiamine (hydrobromide)

Pyrithiamine (hydrobromide)用途

Pyrithiamine hydrobromide is the pyridine analog of thiamine that prevents growth of organisms that require intact thiamine.

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Pyrithiamine (hydrobromide)名称

[ CAS 号 ]:
534-64-5

[ 中文名 ]:
抗硫胺氢溴酸

[ 英文名 ]:
NEOPYRITHIAMINE HYDROBROMIDE

[英文别名 ]:

neopyrithiamine hydrobromide

Pyrithiamine (hydrobromide)物理化学性质

[ 分子式 ]:
C₁₄H₂₀Br₂N₄O

[ 分子量 ]:
420.14300

[ 精确质量 ]:
418.00000

[ PSA ]:
75.91000

[ 外观性状 ]:
crystalline | off-white to yellow

[ 储存条件 ]:
2-8°C

Pyrithiamine (hydrobromide)安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

Pyrithiamine (hydrobromide)合成路线

详细合成路线

Pyrithiamine (hydrobromide)上下游产品

Pyrithiamine (hydrobromide)上游产品

Pyrithiamine (hydrobromide)下游产品

Pyrithiamine (hydrobromide)文献

Interactions between chronic ethanol consumption and thiamine deficiency on neural plasticity, spatial memory, and cognitive flexibility.

Alcohol. Clin. Exp. Res. 39 , 2143-53, (2015)

Many alcoholics display moderate to severe cognitive dysfunction accompanied by brain pathology. A factor confounded with prolonged heavy alcohol consumption is poor nutrition, and many alcoholics are...

Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus.

Appl. Microbiol. Biotechnol. 99 , 10151-61, (2015)

The opportunistic human pathogen Aspergillus fumigatus produces numerous different natural products. The genetic basis for the biosynthesis of a number of known metabolites has remained unknown. The g...

Thiamine deficiency caused by thiamine antagonists triggers upregulation of apoptosis inducing factor gene expression and leads to caspase 3-mediated apoptosis in neuronally differentiated rat PC-12 cells.

Acta Biochim. Pol. 54(2) , 315-22, (2007)

Recent evidence suggests that alterations in oxidative metabolism induced by thiamine deficiency lead to neuronal cell death. However, the molecular mechanisms underlying this process are still under ...

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