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4-氨基苯甲酰肼

4-氨基苯甲酰肼用途

4-氨基苯甲酰肼是一种不可逆的MPO髓过氧化物酶抑制剂,IC50为0.3µM【1】。用于亚急性中风的研究[2]。

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4-氨基苯甲酰肼名称

[ CAS 号 ]:
5351-17-7

[ 中文名 ]:
4-氨基苯甲酰肼

[ 英文名 ]:
ZMVR DZ

[中文别名 ]:

[英文别名 ]:

EINECS 226-324-4
p-Aminobenzoyl Hydrazide
4-aminobenzhydrazide
Aminostimil
(4-Aminobenzoyl)hydrazide
Amben hydrazide
p-Aminobenzhydrazide
4-Aminobenzoylhydrazide
4-aminobenzenecarbonylhydrazine
4-Aminobenzoic acid hydrazide

4-氨基苯甲酰肼生物活性

[ 描述 ]:

4-氨基苯甲酰肼是一种不可逆的MPO髓过氧化物酶抑制剂,IC50为0.3µM【1】。用于亚急性中风的研究[2]。

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Kettle AJ, et al. Inhibition of myeloperoxidase by benzoic acid hydrazides. Biochem J. 1995 Jun 1;308 ( Pt 2)(Pt 2):559-63.

[2]. Forghani R, et al. Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke. J Cereb Blood Flow Metab. 2015 Mar;35(3):485-93.

4-氨基苯甲酰肼物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 熔点 ]:
225-227 °C(lit.)

[ 分子式 ]:
C₇H₉N₃O

[ 分子量 ]:
151.17

[ 精确质量 ]:
151.074554

[ PSA ]:
81.14000

[ LogP ]:
-0.75

[ 外观性状 ]:
白色结晶粉末

[ 折射率 ]:
1.641

[ 储存条件 ]:
存放于惰性气体之中;避免空气

4-氨基苯甲酰肼MSDS

4-氨基苯甲酰肼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG2580000

CHEMICAL NAME :: Benzoic acid, p-amino-, hydrazide

CAS REGISTRY NUMBER :: 5351-17-7

BEILSTEIN REFERENCE NO. :: 0639053

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H9-N3-O

MOLECULAR WEIGHT :: 151.19

WISWESSER LINE NOTATION :: ZNUYQR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01358

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4-氨基苯甲酰肼安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DG2580000

[ 海关编码 ]:
2928000090

4-氨基苯甲酰肼合成路线

4-氨基苯甲酰肼上下游产品

4-氨基苯甲酰肼上游产品

4-氨基苯甲酰肼下游产品

4-氨基苯甲酰肼海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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Vet. Res. 46 , 23, (2015)

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