美托咪酯

美托咪酯名称

[ CAS 号 ]:
5377-20-8

[ 中文名 ]:
美托咪酯

[ 英文名 ]:
metomidate

[英文别名 ]:

Methoxymol
Aquacalm
R 7315
Etomidate impurity B
Metomidate [INN:BAN]
Metomidato [INN-Spanish]
Metomidatum [INN-Latin]
Metomidate
Methoxymol R-7315
Hypnodil

美托咪酯物理化学性质

[ 密度 ]:
1.13g/cm3

[ 沸点 ]:
379.4ºC at 760mmHg

[ 分子式 ]:
C₁₃H₁₄N₂O₂

[ 分子量 ]:
230.26200

[ 闪点 ]:
183.2ºC

[ 精确质量 ]:
230.10600

[ PSA ]:
44.12000

[ LogP ]:
2.27900

[ 折射率 ]:
1.568

美托咪酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI4025000

CHEMICAL NAME :: Imidazole-5-carboxylic acid, 1-(alpha-methylbenzyl)-, methyl ester

CAS REGISTRY NUMBER :: 5377-20-8

BEILSTEIN REFERENCE NO. :: 0659586

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H14-N2-O2

MOLECULAR WEIGHT :: 230.29

WISWESSER LINE NOTATION :: T5N CNJ AY1&R& EVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972

点击显示

美托咪酯安全信息

[ 海关编码 ]:
2933290090

美托咪酯海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

美托咪酯文献

Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs.

Anesthesiology 121(6) , 1203-16, (2014)

Cyclopropyl-methoxycarbonyl metomidate (CPMM, also known as ABP-700) is a second-generation "soft" (i.e., metabolically labile) etomidate analogue. The purpose of this study was to characterize CPMM's...

Anesthesia induces stress in Atlantic salmon (Salmo salar), Atlantic cod (Gadus morhua) and Atlantic halibut (Hippoglossus hippoglossus).

Fish Physiol. Biochem. 36(3) , 719-30, (2010)

Stress in response to anesthesia with benzocaine, MS-222, metomidate and isoeugenol was studied in Atlantic salmon (Salmo salar), Atlantic halibut (Hippoglossus hippoglossus), and Atlantic cod (Gadus ...

Rates of cortisol increase and decrease in channel catfish and sunshine bass exposed to an acute confinement stressor.

Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 143(1) , 134-9, (2006)

Channel catfish and sunshine bass were exposed to a low-water stress event and allowed to recover in fresh water or a solution of metomidate (dl-1-(1-phenylethyl)-5-(metoxycarbonyl) imidazole hydrochl...

更多文献