硫糖铝

硫糖铝用途

硫糖铝是一种细胞保护剂，已用于预防和治疗几种胃肠道疾病。含有硫糖铝的灌肠可改善炎症并增加中性和酸性粘蛋白的组织含量。中性粘蛋白的含量不随硫糖铝的时间或浓度而变化，而酸性粘蛋白随着浓度和干预时间的增加而增加。与用S.F.灌注的动物相比，发现用硫糖铝（SCF）灌洗的动物中的中性粘蛋白的组织含量显着增加。 0.9％，无论干预的浓度和持续时间。

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硫糖铝作用

用于治疗胃溃疡及十二指肠溃疡，制酸及抑制胃蛋白酶的作用。

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硫糖铝名称

[ CAS 号 ]:
54182-58-0

[ 中文名 ]:
硫糖铝

[ 英文名 ]:
Sucralfate

[中文别名 ]:

胃溃宁

[英文别名 ]:

Venter
Urbal
Sucrate
Succosa
Keal
Citogel
ulcerban
carafate
Ulcar
Sugast

硫糖铝生物活性

[ 描述 ]:

Sucralfate 是一种已被用于预防和治疗多种胃肠疾病的细胞保护剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

研究领域 >> 感染

[体内研究]

硫糖铝是一种细胞保护剂,已用于预防和治疗几种胃肠疾病。含有硫糖铝的灌肠可改善炎症并增加中性和酸性粘蛋白的组织含量。中性粘蛋白的含量不随硫糖铝的时间或浓度而变化,而酸性粘蛋白随着浓度和干预时间的增加而增加。与灌注硫糖铝(SCF)的动物中性粘蛋白组织含量显着增加相比,灌注SF 0.9％的动物,无论干预的浓度和持续时间如何[1]。

[动物实验]

在该研究中使用36只雄性Wistar大鼠（300至350g）。将动物分成两个实验组，每组18只动物。根据所采用的干预方案和干预时间，将每个实验组分为6个亚组（n = 6）。在第一和第二亚组中，12只动物每天接受含有40mL 0.9％盐水溶液（对照亚组）的直肠灌肠，在37℃下持续两周（n = 6）和四周（n = 6）。在第二个亚组中，12只动物每天接受含有40mL浓度为1.0g / kg的硫糖铝（SCF）的直肠灌肠，持续两周（n = 6）和四周（n = 6）。最后，第三亚组的12只动物每天接受含有40mL浓度为2.0g / kg的硫糖铝的灌肠，持续两周（n = 6）和四周（n = 6）。为了使施用的速度和时间标准化，使用输液泵在所有动物中施用灌肠剂，其速度标准化为2 / mL / min [1]。

[参考文献]

[1]. Chaim FM, et al. Evaluation of the application of enemas containing sucralfate in tissue content of neutral and acid mucins in experimental model of diversion colitis. Acta Cir Bras. 2014 Sep;29(9):544-52.

[相关活性小分子]

硫糖铝物理化学性质

[ 分子式 ]:
C₁₂H₁₄Al₁₆O₇₅S₈

[ 分子量 ]:
2046.42

[ PSA ]:
1435.37000

[ 外观性状 ]:
白色非晶形的粉末

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Practically insoluble in water, in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of mineral acids and alkali hydroxides.

硫糖铝MSDS

详细MSDS(安全技术说明书)

硫糖铝毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BD0900000

CHEMICAL NAME :: Aluminum, hexadeca-mu-hydroxytetracosahydroxy(mu(sup 8)-(1,3,4,6-tetra-O-sulfo-beta-D- fructofuranosyl-alpha-D-glucopyranoside tetrakis(hydrogen sulfato)(8-)))hexadeca-

CAS REGISTRY NUMBER :: 54182-58-0

LAST UPDATED :: 199703

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C12-H54-Al16-O75-S8

MOLECULAR WEIGHT :: 2086.82

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 1276 mg/kg/3D-I

TOXIC EFFECTS :: Cardiac - pulse rate

REFERENCE :: CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 35,423,1996

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >12 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,374,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,374,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,374,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,374,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,374,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,374,1982

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硫糖铝安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
BD0900000

[ 海关编码 ]:
29400090

硫糖铝文献

Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers.

Phytomedicine 20(6) , 506-11, (2013)

In continuation of our drug discovery program on Indian medicinal plants, the gastro protective mechanism of chebulinic acid isolated from Terminalia chebula fruit was investigated. Chebulinic acid wa...

Protective effect of Calamintha officinalis Moench leaves against alcohol-induced gastric mucosa injury in rats. Macroscopic, histologic and phytochemical analysis.

Phytother Res. 26(6) , 839-44, (2012)

Calamintha officinalis Moench (Lamiaceae) is an aromatic plant used since ancient times for its preservative and medicinal properties. The plant, known as 'Mentuccia' in Central Italy, is used in cook...

Systematic review: Antacids, H2-receptor antagonists, prokinetics, bismuth and sucralfate therapy for non-ulcer dyspepsia.

Aliment. Pharmacol. Ther. 17(10) , 1215-27, (2003)

Evidence for the effectiveness of antacids, histamine-2 receptor antagonists, bismuth salts, sucralfate and prokinetic therapy in non-ulcer dyspepsia is conflicting.To conduct a systematic review eval...

更多文献

硫糖铝

硫糖铝用途

硫糖铝作用

硫糖铝名称

硫糖铝生物活性

硫糖铝物理化学性质

硫糖铝MSDS

详细MSDS(安全技术说明书)

硫糖铝毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

硫糖铝安全信息

硫糖铝文献

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