Ibogamine-18-carboxylicacid, 20-hydroxy-12-methoxy-, methyl ester, (20S)-

用途

(–)-Voacangarine is an indole alkaloid originally isolated from V. africana that is cytotoxic to HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 cells (IC50s = 20 g/ml).

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名称

[ CAS 号 ]:
545-84-6

[ 英文名 ]:
Ibogamine-18-carboxylicacid, 20-hydroxy-12-methoxy-, methyl ester, (20S)-

[英文别名 ]:

COACRISTINE
voacristine
Voacangarin

物理化学性质

[ 密度 ]:
1.32g/cm3

[ 沸点 ]:
542.9ºC at 760 mmHg

[ 分子式 ]:
C₂₂H₂₈N₂O₄

[ 分子量 ]:
384.46900

[ 闪点 ]:
282.1ºC

[ 精确质量 ]:
384.20500

[ PSA ]:
74.79000

[ LogP ]:
2.17250

[ 折射率 ]:
1.648

[ 储存条件 ]:
-20°C，密闭，干燥

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NH6737100

CHEMICAL NAME :: Ibogamine-18-carboxylic acid, 20-hydroxy-12-methoxy-, methyl ester, (20S)-

CAS REGISTRY NUMBER :: 545-84-6

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H28-N2-O4

MOLECULAR WEIGHT :: 384.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 100 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 171,17,1986