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泰妙菌素

泰妙菌素用途

本品抗菌谱与与大环内酯类抗生素相似，主要抗革兰氏阳性菌，对金黄色葡萄球菌、链球菌、支原体、猪胸膜肺炎放线杆菌、猪密螺旋体痢疾等有较强的抑制作用，对支原体的作用强与大环内酯类。对革兰氏阴性菌尤其是肠道菌作用较弱。

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泰妙菌素名称

[ CAS 号 ]:
55297-95-5

[ 中文名 ]:
硫姆林

[ 英文名 ]:
Tiamulin

[中文别名 ]:

泰妙菌素

[英文别名 ]:

Tiamulin
EINECS 259-580-0
MFCD01672098
thiamutilin
TiaMulin fuMerate API
tiavetp
Tiamutin
TIAMILIN

泰妙菌素生物活性

[ 描述 ]:

Tiamulin fumarate (Thiamutilin fumarate) 是一类二萜兽药,广泛用于控制猪的传染疾病,包括猪痢疾和地方性肺炎等。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Noa M, et al. Tiamulin-nitrovin interaction in pigs: a case report and experimental reproduction. Vet Hum Toxicol. 2000 Oct;42(5):286-8.

[2]. Dreyfuss J, et al. Metabolism of tritium- and carbon-14-labeled tiamulin in dogs, rats, and pigs. J Antibiot (Tokyo). 1979 May;32(5):496-503.

[3]. Islam KM, et al. The activity and compatibility of the antibiotic tiamulin with other drugs in poultry medicine--A review. Poult Sci. 2009 Nov;88(11):2353-9.

泰妙菌素物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
563.0±50.0 °C at 760 mmHg

[ 熔点 ]:
147-148ºC

[ 分子式 ]:
C₂₈H₄₇NO₄S

[ 分子量 ]:
493.742

[ 闪点 ]:
294.3±30.1 °C

[ 精确质量 ]:
493.322571

[ PSA ]:
92.14000

[ LogP ]:
5.93

[ 蒸汽压 ]:
0.0±3.5 mmHg at 25°C

[ 折射率 ]:
1.541

[ 储存条件 ]:
2-8°C

泰妙菌素安全信息

[ 危害声明 ]:
H413

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
AG9552000

泰妙菌素合成路线

详细合成路线

泰妙菌素上下游产品

泰妙菌素上游产品

泰妙菌素下游产品

泰妙菌素文献

[Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo].

Zhongguo Zhong Yao Za Zhi 37(9) , 1311-4, (2012)

To study the pharmacokinetics of single administration and different compatibility of tetramethylpyrazine (TMP) in rats.Thirty two Sprague-Dawley rats were randomly divided into 4 groups: the TMP (30 ...

Design, synthesis, and antibacterial activity of novel pleuromutilin derivatives bearing an amino thiazolyl ring.

Arch. Pharm. (Weinheim) 345(8) , 638-46, (2012)

A series of novel pleuromutilin derivatives containing the amino thiazolyl ring were designed, synthesized, and evaluated for their antibacterial activities in vitro against Gram-positive clinical bac...

Simultaneous determination of three classes of antibiotics in the suspended solids of swine wastewater by ultrasonic extraction, solid-phase extraction and liquid chromatography-mass spectrometry.

J. Environ. Sci. (China) 23(10) , 1729-37, (2011)

This work describes a systematic approach to the development of a method for simultaneous determination of three classes of veterinary antibiotics in the suspended solids (SS) of swine wastewater, inc...

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