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S-文拉法辛

S-文拉法辛用途

S-(-)-华法林是华法林作为维生素K拮抗剂更有效的对映体,具有抗凝作用[1]。

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S-文拉法辛名称

[ CAS 号 ]:
5543-57-7

[ 中文名 ]:
(S)-(-)-华法令

[ 英文名 ]:
Warfarin

[中文别名 ]:

(S)-华法林

[英文别名 ]:

ATHROMBIN
(-)-Warfarin
(S)-Warfarin
MFCD00272381
Varfine
Tintorane
3-a-Phenyl-b-acetylethyl-4-hydroxycoumarin
Warfarin
(±)-Warfarin
(RS)-Warfarin

S-文拉法辛生物活性

[ 描述 ]:

S-(-)-华法林是华法林作为维生素K拮抗剂更有效的对映体,具有抗凝作用[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Bai J, et al. Metabolic profiling of HepG2 cells incubated with S(-) and R(+) enantiomers of anti-coagulating drug warfarin. Metabolomics. 2011 Sep;7(3):353-362.

S-文拉法辛物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
515.2±50.0 °C at 760 mmHg

[ 熔点 ]:
≥170ºC

[ 分子式 ]:
C₁₉H₁₆O₄

[ 分子量 ]:
308.328

[ 闪点 ]:
188.8±23.6 °C

[ 精确质量 ]:
308.104858

[ PSA ]:
67.51000

[ LogP ]:
3.42

[ 外观性状 ]:
white to pale yellow

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.635

[ 储存条件 ]:
2-8°C

S-文拉法辛MSDS

详细MSDS(安全技术说明书)

S-文拉法辛安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360D-H372-H412

[ 警示性声明 ]:
P201-P273-P308 + P313

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
61-48/25-52/53

[ 安全声明 (欧洲) ]:
53-45-61

[ 危险品运输编码 ]:
UN 2811 6.1/PG 1

[ WGK德国 ]:
3

S-文拉法辛文献

Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes.

J. Thromb. Haemost. 8(12) , 2708-17, (2010)

Warfarin, an antagonist of vitamin K, is an oral coumarin anticoagulant widely used to control and prevent thromboembolic disorders. Warfarin is clinically available as a racemic mixture of R- and S-w...

Secreted protein profile from HepG2 cells incubated by S(-) and R(+) enantiomers of chiral drug warfarin - An analysis in cell-based system and clinical samples.

Proteomics. Clin. Appl. 4(10-11) , 808-15, (2010)

warfarin is a commonly prescribed oral anticoagulant with narrow therapeutic index. It interferes with the vitamin K cycle to achieve anti-coagulating effects. Warfarin has two enantiomers, S(-) and R...

Chemical modification with high molecular weight polyethylene glycol reduces transduction of hepatocytes and increases efficacy of intravenously delivered oncolytic adenovirus.

Hum. Gene Ther. 20(9) , 975-88, (2009)

Oncolytic adenoviruses are anticancer agents that replicate within tumors and spread to uninfected tumor cells, amplifying the anticancer effect of initial transduction. We tested whether coating the ...

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