阿考达唑

阿考达唑名称

[ CAS 号 ]:
55435-65-9

[ 中文名 ]:
阿考达唑

[ 英文名 ]:
Acetamide,N-methyl-N-[4-[(7-methyl-1H-imidazo[4,5-f]quinolin-9-yl)amino]phenyl]-,hydrochloride (1:1)

[英文别名 ]:

Acodazole HCl
Acodazole hydrochloride (USAN)
ACODAZOLE HYDROCHLORIDE

阿考达唑物理化学性质

[ 沸点 ]:
628ºC at 760 mmHg

[ 分子式 ]:
C₂₀H₂₀ClN₅O

[ 分子量 ]:
381.85900

[ 闪点 ]:
333.6ºC

[ 精确质量 ]:
381.13600

[ PSA ]:
73.91000

[ LogP ]:
5.02080

阿考达唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC6148500

CHEMICAL NAME :: Acetamide, N-methyl-N-(4-((7-methyl-1H-imidazo(4,5-f)quinolin-9- yl)amino)phenyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 55435-65-9

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H19-N5-O.Cl-H

MOLECULAR WEIGHT :: 381.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 24300 ug/kg/4W-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,3895,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 161 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 87590 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

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