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Nε,Nε,Nε-Trimethyllysine chloride

用途

Nε,Nε,Nε-Trimethyllysine chloride 作为肠道菌群依赖性形成 N,N,N-trimethyl-5-aminovaleric acid (TMAVA) 的前体。

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名称

[ CAS 号 ]:
55528-53-5

[ 中文名 ]:
Nε,Nε,Nε-三甲基赖氨酸盐酸盐

[ 英文名 ]:
Nε,Nε,Nε-Trimethyllysine chloride

[英文别名 ]:

生物活性

[ 描述 ]:

Nε,Nε,Nε-Trimethyllysine chloride 作为肠道菌群依赖性形成 N,N,N-trimethyl-5-aminovaleric acid (TMAVA) 的前体。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

TMAVA是由Nε,Nε,Nε-三甲基赖氨酸氯化物生成的新型肠道菌群代谢物[1]。

[参考文献]

[1]. Zhao M, et al. TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice. Gastroenterology. 2020;158(8):2266-2281.e27.

物理化学性质

[ 分子式 ]:
C₉H₂₁ClN₂O₂

[ 分子量 ]:
224.72800

[ 精确质量 ]:
224.12900

[ PSA ]:
66.15000

[ LogP ]:
0.44240

[ 储存条件 ]:
-20°C

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Inhibition of histone binding by supramolecular hosts.

Biochem. J. 459(3) , 505-12, (2014)

The tandem PHD (plant homeodomain) fingers of the CHD4 (chromodomain helicase DNA-binding protein 4) ATPase are epigenetic readers that bind either unmodified histone H3 tails or H3K9me3 (histone H3 t...

A new type of protein lysine methyltransferase trimethylates Lys-79 of elongation factor 1A.

Biochem. Biophys. Res. Commun. 455(3-4) , 382-9, (2014)

The elongation factors of Saccharomyces cerevisiae are extensively methylated, containing a total of ten methyllysine residues. Elongation factor methyltransferases (Efm1, Efm2, Efm3, and Efm4) cataly...

Tuning HP1α chromodomain selectivity for di- and trimethyllysine.

ChemBioChem. 12(18) , 2786-90, (2011)

Histone lysine methylation is a critical marker for controlling gene expression. The position and extent of methylation (mono-, di-, or tri-) controls the binding of effector proteins that determine w...

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