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beta-香树精

beta-香树精用途

β-Amyrin 是番茄果实的表面蜡和蒲公英咖啡中的一种成分,能阻断淀粉样 β (Aβ) 诱导的增强效应损害。β-amyrin 是一种有前景成为治疗 AD 的候选药物。

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beta-香树精名称

[ CAS 号 ]:
559-70-6

[ 中文名 ]:
β-香树精

[ 英文名 ]:
beta-Amyrin

[中文别名 ]:

[英文别名 ]:

B-AMYRIN
MFCD00017381
(3β)-Olean-12-én-3-ol
Olean-12-en-3-ol
(3β)-Olean-12-en-3-ol
β-Amyrenol
β-amyrin
Olean-12-en-3b-ol
AMYRIN,B
Olean-12-en-3-ol, (3β)-

beta-香树精生物活性

[ 描述 ]:

β-Amyrin 是番茄果实的表面蜡和蒲公英咖啡中的一种成分,能阻断淀粉样 β (Aβ) 诱导的增强效应损害。β-amyrin 是一种有前景成为治疗 AD 的候选药物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Park HJ, et al. β-Amyrin Ameliorates Alzheimer's Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus. Biomol Ther (Seoul). 2019 Jul 30.

beta-香树精物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
490.7±44.0 °C at 760 mmHg

[ 熔点 ]:
187-190°C

[ 分子式 ]:
C₃₀H₅₀O

[ 分子量 ]:
426.717

[ 闪点 ]:
217.7±20.7 °C

[ 精确质量 ]:
426.386169

[ PSA ]:
20.23000

[ LogP ]:
11.06

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.539

[ 储存条件 ]:
2-8℃，干燥

beta-香树精MSDS

beta-香树精安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

beta-香树精合成路线

beta-香树精上下游产品

beta-香树精上游产品

beta-香树精下游产品

beta-香树精制备

1. 从石油醚或乙醇中得针晶。

2. 烟草：FC，41；FC，8；可由δ-Amylene转化而得。

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beta-香树精文献

β-Amyrin biosynthesis: the critical role of steric volume at C-19 of 2,3-oxidosqualene for its correct folding to generate the pentacyclic scaffold.

Org. Lett. 16(13) , 3548-51, (2014)

The effect of the steric volume at C-19 of (3S)-2,3-oxidosqualene 1 on the polycyclization reaction by β-amyrin synthase was examined. The substrate analogs, in which the methyl group at C-19 of 1 was...

Comparative analysis of CYP93E proteins for improved microbial synthesis of plant triterpenoids.

Phytochemistry 108 , 47-56, (2014)

Cytochrome P450-dependent monooxygenases (P450s) belonging to the CYP93E subfamily catalyze the C-24 oxidation of the triterpene backbone during the biosynthesis of triterpenoid saponins, which are bi...

Antitrypanosomal triterpenoid with an ε-lactone E-ring from Salvia urmiensis.

J. Nat. Prod. 76(9) , 1806-9, (2013)

A new triterpenoid, urmiensolide (1), was isolated from Salvia urmiensis. The structure was elucidated by a combination of 1D and 2D NMR, HRESIMS, and X-ray crystallographic analyses. The absolute con...

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