甲基毒死蜱
甲基毒死蜱用途
广谱性杀虫剂，通过触杀、胃毒和熏蒸均有效
【用途二】
广谱性有机磷杀虫剂，具有触杀、胃毒和熏蒸作用，无内吸作用。用于防治贮藏谷物中的害虫和各种叶类作物上的害虫，也可用于防治蚊、蝇等卫生害虫，在土壤中无持效性。如药剂用于原粮贮藏时，可有效防治玉米象、杂拟谷盗、锯谷盗、赤拟谷盗等。施药量为1000kg稻谷喷1000mL（有效浓度10～20mg/kg)的药液（或撒1kg拌药的砻糠）。采用边倒粮食边喷（撒）药的方法。对谷蠹和螨类、书虱的防治效果不理想。
【用途三】
甲基毒死蜱是一种广谱性杀虫剂。解杀、胃毒和薰蒸均有效，无内吸性，主要用于防治谷物贮藏过程中的害虫。
【用途四】
甲基毒死蜱是一种广谱性杀虫剂。解杀、胃毒和薰蒸均有效，无内吸性，主要用于防治谷物贮藏过程中的害虫。校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。
甲基毒死蜱名称
[ CAS 号 ]:
5598-13-0
[ 中文名 ]:
甲基毒死蜱
[ 英文名 ]:
Chlorpyrifos-methyl
[中文别名 ]:
[英文别名 ]:
- EINECS 227-011-5
- Chlorpyrifos-methyl
- MFCD00055310
甲基毒死蜱物理化学性质
[ 密度 ]:
1.6±0.1 g/cm3
[ 沸点 ]:
347.3±52.0 °C at 760 mmHg
[ 熔点 ]:
45.5-46.5°C
[ 分子式 ]:
C7H7Cl3NO3PS
[ 分子量 ]:
322.533
[ 闪点 ]:
163.8±30.7 °C
[ 精确质量 ]:
320.894989
[ PSA ]:
82.48000
[ LogP ]:
3.71
[ 外观性状 ]:
无色晶体带有一种像氨一样的气味
[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C
[ 折射率 ]:
1.582
[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运
甲基毒死蜱MSDS
甲基毒死蜱毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TG0700000
- CHEMICAL NAME :
- Phosphorothioic acid, O,O-dimethyl O-(3,5,6-trichloro-2-pyridyl) ester
- CAS REGISTRY NUMBER :
- 5598-13-0
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C7-H7-Cl3-N-O3-P-S
- MOLECULAR WEIGHT :
- 322.53
- WISWESSER LINE NOTATION :
- T6NJ BOPS&O1&O1 CG EG FG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,369,1972 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1828 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - tremor Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- HOEKAN Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute of Public Health. (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060, Japan) No.1- 1951- Volume(issue)/page/year: 23,57,1973
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >670 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,168,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3713 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 35,1315,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 30,409,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1710 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986- Volume(issue)/page/year: 9,57,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2032 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - tremor Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- HOEKAN Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute of Public Health. (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060, Japan) No.1- 1951- Volume(issue)/page/year: 23,57,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 37,427,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2325 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 65,144,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 23800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 30,409,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BESAAT Bulletin of the Entomological Society of America. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1955- Volume(issue)/page/year: 15,123,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,168,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C74,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- >7950 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,168,1991
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - domestic
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 31,60,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 13 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1529 mg/kg/26W-C
- TOXIC EFFECTS :
- Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- HOEKAN Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute of Public Health. (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060, Japan) No.1- 1951- Volume(issue)/page/year: 23,71,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - domestic
- DOSE/DURATION :
- 1875 mg/kg/25D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 31,60,1989
甲基毒死蜱安全信息
[ 符号 ]:
GHS02, GHS07
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H302-H312-H319-H332
[ 警示性声明 ]:
P210-P280-P305 + P351 + P338
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
Xi:Irritant;N:Dangerousfortheenvironment;
[ 风险声明 (欧洲) ]:
R43;R50/53
[ 安全声明 (欧洲) ]:
S36/37-S60-S61-S36-S26-S16
[ 危险品运输编码 ]:
UN 3077
[ RTECS号 ]:
TG0700000
[ 海关编码 ]:
2933399026
甲基毒死蜱上下游产品
甲基毒死蜱上游产品
甲基毒死蜱下游产品
甲基毒死蜱制备
1. 五氯吡啶的合成 吡啶催化氯化得到五氯吡啶。2.2,3,5,6-四氯吡啶的合成 五氯吡啶与锌粉和氯化铵反应得四氯吡啶。3.3,5,6-三氯-2-吡啶醇的合成 四氯吡啶和KOH反应得3,5,6-三氯-2-吡啶醇。4.甲基毒死蜱的合成 3,5,6-三氯-2-吡啶醇，与O,O-二甲基硫化磷酰氯，反应得甲基毒死蜱。
2. 五氯吡啶的制备 将4～6目活性炭60mL浸渍于内含1.5g氯化钴的150mL水溶液中，加热蒸水至干，得催化剂。然后将催化剂用氯气预处理，在镍制反应管内，升温至330℃，将汽化的吡啶、氯气和氮气充分混合，送入催化剂层进行反应而得五氯吡啶，纯度99.5%。
2,3,5,6-四氯吡啶的制备 将199g乙腈、35g五氯吡啶，加热回流，完全溶解。再加入锌粉9.6g，并将由15g氯化铵和40mL水配成的溶液，缓慢地滴加至上述混合物中，反应适当时间后，补加稀盐酸， 于77～78℃下蒸馏得四氯吡啶。
3，5，6-三氯-2-吡啶醇的制备 将217g四氯吡啶、868g水、128gKOH混合物于95～100℃搅拌反应，趁热过滤，使滤液温度为85℃，向滤液中加浓硫酸，使pH值达3.5，冷却至50℃，热水洗涤滤饼、烘干。
3，5，6-三氯-2-吡啶醇的合成 可参见毒死蜱的制备方法。
O，O-二甲基硫代磷酰氯的制备 参见杀螟硫磷的制备方法。
甲基毒死蜱的合成 投入3，5，6-三氯-2-吡啶醇、氢氧化钠和水，加热使固体物完全消失，降温后再分别加入氯化钠、氢氧化钠、硼酸、苄基三乙基氯化铵、1-甲基咪唑和二氯甲烷，在室温搅拌，滴加O，O-二甲基硫代磷酰氯，滴毕，升温回流1～1.5h，冷却，静置分层、水洗、减压脱溶制得。
甲基毒死蜱海关
[ 海关编码 ]: 2933399026
甲基毒死蜱文献
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Total diet study on pesticide residues in France: Levels in food as consumed and chronic dietary risk to consumersEnviron. Int. 45 , 135-50, (2012)
Chronic dietary exposure to pesticide residues was assessed for the French population using a total diet study (TDS) to take into account realistic levels in foods as consumed at home (table-ready). T...
Washing effects of limonene on pesticide residues in green peppers.J. Sci. Food Agric. 93(12) , 2917-21, (2013)
The presence of pesticide residues in food has caused much concern. The low health risks and environmental impacts of limonene make it a very interesting solvent for use in green chemistry. Washing ef...
推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥178.0/1ml
￥178.0/1ml
联系人：刘佳
产品详情：甲基毒死蜱标准溶液
公司名：上海源溪生物科技有限公司
区域：上海市浦东新区
价格：
￥需询单/1g
联系人：赖经理
产品详情：Chlorpyrifos-methyl
公司名：上海脉铂医药科技有限公司
区域：上海市嘉定区
价格：
￥1540.0/5mg
￥389.0/1mg
￥2282.0/10mg
￥需询单/1g
联系人：李先生
产品详情：Chlorpyrifos-methyl
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥154.9/1ml
￥720.9/1ml
￥926.9/250mg
￥926.9/1ml
联系人：阿拉丁李高志
产品详情：甲基毒死蜱
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相关化合物
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