S-(2-氨乙基)异硫脲溴鎓氢溴酸盐
S-(2-氨乙基)异硫脲溴鎓氢溴酸盐用途
用于有机合成，酶激活剂，辐射病预防，游离基的解毒剂。该品作为药物能促进脑细胞代谢，增加对碳水化合物的利用，提高中枢兴奋性。能使外伤性昏迷病人迅速地恢复脑的功能，并有对抗中枢抑制药物的作用。适用于外伤性昏迷、心血管疾患所致的昏迷、一氧化碳中毒、巴比妥类及安定药物的中毒、放射性损伤及脑缺氧等。
S-(2-氨乙基)异硫脲溴鎓氢溴酸盐名称
[ CAS 号 ]:
56-10-0
[ 中文名 ]:
乙胺硫脲
[ 英文名 ]:
S-(2-Aminoethyl)pseudothiourea dihydrobromide
[中文别名 ]:
- 异硫脲酸2-氨基乙酯二溴氢酸盐
- 抗利痛
- S-(2-氨乙基)异硫脲溴摀氢溴酸盐
- S-(2-氨乙基)异硫脲二氢溴酸盐
- 2-(2-氨乙基)-2-异硫脲二氨溴酸盐
- S-(2-胺乙基)异硫脲氢溴酸盐
- 克脑迷
- 2-氨乙基异硫脲氢溴酸盐
- S-(2-氨乙基)异硫脲溴鎓氢溴酸盐
- S-(2-氨乙基)异硫脲溴鎓氢溴酸盐
[英文别名 ]:
- b-aminoethylisothiuronium bromide hydrobromide
- 2-(β-Aminoethyl)isothiuronium bromide hydrobromide
- S-(β-Aminoethyl)isothiuronium bromide hydrobromide
- S-(2-Aminoethyl)isothiuronium bromide hydrobromide
- 2-Aminoethyl carbamimidothioate dihydrobromide
- 2-AMINOETHYLISO-THIOURONIUM BROMIDE
- surrectan
- AET,DiHBr
- AET,DIHYDROBROMIDE
- 2-Aminoethylisothiouronium bromide hydrochloride
S-(2-氨乙基)异硫脲溴鎓氢溴酸盐物理化学性质
[ 沸点 ]:
231.1ºC at 760mmHg
[ 熔点 ]:
190-196 °C(lit.)
[ 分子式 ]:
C3H11Br2N3S
[ 分子量 ]:
281.013
[ 闪点 ]:
93.6ºC
[ 精确质量 ]:
278.904022
[ PSA ]:
101.19000
[ LogP ]:
2.98830
[ 外观性状 ]:
固体;White to Almost white powder to crystal
[ 储存条件 ]:
库房通风低温干燥
[ 水溶解性 ]:
水溶性：可溶
S-(2-氨乙基)异硫脲溴鎓氢溴酸盐MSDS
S-(2-氨乙基)异硫脲溴鎓氢溴酸盐毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UM0175000
- CHEMICAL NAME :
- Pseudourea, (2-aminoethyl)-2-thio-, dihydrobromide
- CAS REGISTRY NUMBER :
- 56-10-0
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C3-H9-N3-S.2Br-H
- MOLECULAR WEIGHT :
- 281.05
- WISWESSER LINE NOTATION :
- Z2SYZUM &EH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 288 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 85 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 815 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 242 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 85400 ug/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 177 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 113 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 236 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 356 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5474 mg/kg/40D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 415 mg/kg/15D-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Related to Chronic Data - death
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 334,317,1995
S-(2-氨乙基)异硫脲溴鎓氢溴酸盐安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302-H315-H319-H335
[ 警示性声明 ]:
P261-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R22;R36/37/38
[ 安全声明 (欧洲) ]:
S26-S36/37-S22
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
UM0175000
S-(2-氨乙基)异硫脲溴鎓氢溴酸盐合成路线
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S-(2-氨乙基)异硫脲溴鎓氢溴酸盐制备
（1）由氨基乙醇溴化得到溴乙胺氢溴酸盐后，与硫脲缩合而得：溴化：在反应罐中投入氢溴酸，冷却后，搅拌下滴加氨基乙醇，于30min内滴加完毕，然后蒸出投入量85%的氢溴酸，约20h蒸完。浓缩液冷却至70-80℃后将其放入预先冷冻的丙酮中，再冷却至5℃以下结晶，过滤，用冷丙酮洗涤，干燥，得溴乙胺氢溴酸盐。熔点165℃。缩合：将异丙醇和硫脲混合搅拌，加热至70℃，迅速加入溴乙胺氢溴酸盐，内温升至82℃，反应40min。冷至10℃以下过滤，用冷异丙醇洗涤，再用少量乙酸乙酯洗涤，干燥，得克脑迷粗品。在粗品中加入4.75倍甲醇（V/V），0.02倍活性炭，搅拌加热回流15-20min。趁热过滤，冷却，半小时后加入粗品量的4.28倍乙醚（V/V）。继续冷却，待结晶完全后过滤，干燥，得成品。总收率56-58%（对氨基乙醇计）。（2）以环乙胺、氢溴酸、硫脲为原料合成：先将硫脲与溴氢酸混合，在150℃以下滴加环乙胺，待反应完成后，加入活性炭过滤，然后减压脱水，温度在50℃以下即析出结晶，过滤，以无水乙醇洗两次，即得成品。
S-(2-氨乙基)异硫脲溴鎓氢溴酸盐文献
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价格：
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标题：56-10-0_S-(2-氨乙基)异硫脲溴鎓氢溴酸盐CAS号:56-10-0_S-(2-氨乙基)异硫脲溴鎓氢溴酸盐【结构式 性质 英文】 - 化源网 地址：https://m.chemsrc.com/mip/cas/56-10-0_325164.html