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α-羟基美托洛尔(非对映异构体混合物)

α-羟基美托洛尔(非对映异构体混合物)用途

a-Hydroxymetoprolol 是美托洛尔的代谢产物。a-Hydroxymetoprolol 对美托洛尔的肾上腺素受体阻断作用几乎为零。

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α-羟基美托洛尔(非对映异构体混合物)名称

[ CAS 号 ]:
56392-16-6

[ 中文名 ]:
A-羟基美托洛尔

[ 英文名 ]:
UNII:C19D0413EL

[中文别名 ]:

Alpha-羟基美托洛尔

[英文别名 ]:

α-HYDROXYMETOPROLOL
UNII:C19D0413EL

α-羟基美托洛尔(非对映异构体混合物)生物活性

[ 描述 ]:

a-Hydroxymetoprolol 是美托洛尔的代谢产物。a-Hydroxymetoprolol 对美托洛尔的肾上腺素受体阻断作用几乎为零。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Hoffmann KJ, et al. The effect of impaired renal function on the plasma concentration and urinary excretion of metoprolol metabolites. Clin Pharmacokinet. 1980 Mar-Apr;5(2):181-91.

α-羟基美托洛尔(非对映异构体混合物)物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
437.6±45.0 °C at 760 mmHg

[ 熔点 ]:
65-67ºC

[ 分子式 ]:
C₁₅H₂₅NO₄

[ 分子量 ]:
283.363

[ 闪点 ]:
218.4±28.7 °C

[ 精确质量 ]:
283.178345

[ PSA ]:
70.95000

[ LogP ]:
0.72

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.524

[ 储存条件 ]:
-20°C Freezer

α-羟基美托洛尔(非对映异构体混合物)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA4907000

CHEMICAL NAME :: Benzenemethanol, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-alpha-( methoxymethyl)-

CAS REGISTRY NUMBER :: 56392-16-6

LAST UPDATED :: 198809

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H25-N-O4

MOLECULAR WEIGHT :: 283.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,186,1979

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α-羟基美托洛尔(非对映异构体混合物)安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

α-羟基美托洛尔(非对映异构体混合物)合成路线

详细合成路线

α-羟基美托洛尔(非对映异构体混合物)上下游产品

α-羟基美托洛尔(非对映异构体混合物)上游产品

α-羟基美托洛尔(非对映异构体混合物)下游产品

α-羟基美托洛尔(非对映异构体混合物)文献

Simultaneous determination of metoprolol and α-hydroxymetoprolol in human plasma using excitation-emission matrix fluorescence coupled with second-order calibration methods.

Bioanalysis 4(23) , 2781-93, (2012)

Metoprolol (MET) is a β1-adrenoceptor antagonist, which is widely used in the treatment of cardiovascular diseases, and α-hydroxymetoprolol (α-OHM) is its hydroxylated metabolite. Owing to their simil...

Metoprolol oxidation polymorphism in Brazilian elderly cardiac patients.

J. Pharm. Pharmacol. 65(9) , 1347-53, (2013)

The purpose of this study was to phenotype the CYP2D6 in elderly with heart disease classified as extensive metabolizer or poor metabolizers (PM) of metoprolol, develop and validate the method of anal...

Variation of pharmacokinetics after oral administration of slow-release metoprolol tablets and pharmacogenetic considerations.

Arzneimittelforschung 42(6) , 802-6, (1992)

The maximum plasma concentrations (Cmax) after oral administration of 120 mg tablets of slow-release metoprolol (CAS 37350-58-6) to 75 Japanese healthy male volunteers and 15 arrhythmic patients were ...

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