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7-酮基胆固醇

7-酮基胆固醇用途

7-酮胆固醇,有毒的氧化甾醇,抑制胆汁酸生物合成胆固醇7α羟化酶的限速步骤,并强烈抑制HMG-CoA还原酶(胆固醇生物合成的限速酶)。7-酮胆固醇诱导细胞凋亡[1]。

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7-酮基胆固醇名称

[ CAS 号 ]:
566-28-9

[ 中文名 ]:
5-胆甾烯-3β-醇-7-酮

[ 英文名 ]:
7-KETOCHOLESTEROL

[中文别名 ]:

胆甾-3-羟基-5-烯-7-酮

[英文别名 ]:

cholest-3,5-dien-7-one
Cholest-5-en-7-one, 3-hydroxy-, (3β)-
3b-Hydroxycholest-5-en-7-one
Cholesta-3,5-dien-7-on
7-KETOCHOLESTEROL
7-Ketocholesta-3,5-diene
(3β)-3-Hydroxycholest-5-en-7-one
3,5-cholestadien-7-one
Cholesta-3,5-diene-7-one-d7
7-oxo-3,5-cholestadiene

7-酮基胆固醇生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. M A Lyons, et al. 7-Ketocholesterol. Int J Biochem Cell Biol. Mar-Apr 1999;31(3-4):369-75.

[2]. Amelia Anderson, et al. 7-Ketocholesterol in disease and aging. Redox Biol. 2020 Jan;29:101380.

7-酮基胆固醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
516.7±29.0 °C at 760 mmHg

[ 熔点 ]:
158-160ºC

[ 分子式 ]:
C₂₇H₄₄O₂

[ 分子量 ]:
400.637

[ 闪点 ]:
218.5±16.9 °C

[ 精确质量 ]:
400.334137

[ PSA ]:
37.30000

[ LogP ]:
7.57

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.531

[ 储存条件 ]:
-20°C

7-酮基胆固醇MSDS

详细MSDS(安全技术说明书)

7-酮基胆固醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ8708000

CHEMICAL NAME :: Cholesterol, 7-oxo-

CAS REGISTRY NUMBER :: 566-28-9

BEILSTEIN REFERENCE NO. :: 2169084

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H44-O2

MOLECULAR WEIGHT :: 400.71

WISWESSER LINE NOTATION :: L E5 B666 KV LUTJ A1 E1 FY1&3Y1&1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg/9W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 25 umol/L

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,1103,1986

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7-酮基胆固醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

7-酮基胆固醇文献

Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo.

J. Cell. Mol. Med. 16(10) , 2331-41, (2012)

A number of cardioprotective effects, including the reduced oxidation of the low-density lipoprotein (LDL) particles, have been attributed to dietary soy isoflavones. Paraoxonase 1 (PON1), an enzyme m...

On-line liquid chromatography-gas chromatography: A novel approach for the analysis of phytosterol oxidation products in enriched foods.

J. Chromatogr. A. 1396 , 98-108, (2015)

A novel methodology for the automated qualitative and quantitative determination of phytosterol oxidation products in enriched foods via on-line liquid chromatography-gas chromatography (LC-GC) was es...

Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.

J. Chromatogr. A. 1364 , 214-22, (2014)

We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of...

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