纳洛芬
纳洛芬名称
[ CAS 号 ]:
57-29-4
[ 中文名 ]:
纳洛芬
[ 英文名 ]:
nalorphine hydrochloride ciii (250 mg)
[英文别名 ]:
- N-Allylnormorphine hydrochloride
- Miromorfalil
- EINECS 200-321-8
- Nalorphine hydrochloride
- Nalorphine HCl
- Normorphine,N-allyl-,hydrochloride
- Allylmorphine hydrochloride
- DEA No. 9400
- Nalline
纳洛芬物理化学性质
[ 沸点 ]:
493.6ºC at 760 mmHg
[ 熔点 ]:
208ºC
[ 分子式 ]:
C19H22ClNO3
[ 分子量 ]:
347.83600
[ 闪点 ]:
11ºC
[ 精确质量 ]:
347.12900
[ PSA ]:
52.93000
[ LogP ]:
2.49420
[ 外观性状 ]:
solid | white
[ 储存条件 ]:
2-8°C
[ 水溶解性 ]:
H2O: slightly soluble
纳洛芬MSDS
纳洛芬毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QC7710000
- CHEMICAL NAME :
- Morphinan-3,6-alpha-diol, 17-allyl-7,8-didehydro-4,5-alpha-epoxy-, hydrochloride
- CAS REGISTRY NUMBER :
- 57-29-4
- LAST UPDATED :
- 199306
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C19-H21-N-O3.Cl-H
- MOLECULAR WEIGHT :
- 347.87
- WISWESSER LINE NOTATION :
- T B6566 B6/CO 4ABBC R BX HO PN DU GHT&&TTJ FQ JQ P2U1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 143 ug/kg
- TOXIC EFFECTS :
- Behavioral - euphoria Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis
- REFERENCE :
- AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 113,887,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1150 mg/kg
- TOXIC EFFECTS :
- Behavioral - analgesia
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,48,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1460 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 447 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 103,489,1955
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 505 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,593,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 63 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 111,152,1954
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Behavioral - analgesia
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,571,1964 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 350 mg/kg
- SEX/DURATION :
- male 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 14,481,1967
纳洛芬安全信息
[ 符号 ]:
GHS02, GHS06, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H301 + H311 + H331-H370
[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311
[ 危害码 (欧洲) ]:
Xn,T,F
[ 风险声明 (欧洲) ]:
22-39/23/24/25-23/24/25-11
[ 安全声明 (欧洲) ]:
36/37/39-45-36/37-16-7
[ 危险品运输编码 ]:
UN 1230 3/PG 2
[ WGK德国 ]:
3
[ RTECS号 ]:
QC7710000
纳洛芬文献
BMC Res. Notes 5 , 439, (2012)
Naltrexone has been proven to be an effective treatment option for the treatment of alcohol dependency. In this article we introduce a reliable and simple method developed for the simultaneous determi...
GC-MS confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine.J. Anal. Toxicol. 23(3) , 177-86, (1999)
A procedure for the simultaneous confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine specimens by gas chromatography-mass spectrometry ...
Comparison of stably expressed rat UGT1.1 and UGT2B1 in the glucuronidation of opioid compounds.Drug Metab. Dispos. 25(2) , 251-5, (1997)
Opioids are important drugs used as analgesics, antitussives, antidiarrheals, and in the therapy of myocardial infarctions, and as antagonists of opioid intoxication. The glucuronidation of these comp...
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