4-AMINO-5-CHLORO-2-METHOXY-N-PIPERIDIN-4-YL-BENZAMIDE
名称
[ CAS 号 ]:
57645-49-5
[ 英文名 ]:
4-AMINO-5-CHLORO-2-METHOXY-N-PIPERIDIN-4-YL-BENZAMIDE
[英文别名 ]:
- Desbenzylclebopride
- N-<4'-Piperidyl>-2-methoxy-4-amino-5-chlorbenzamid
物理化学性质
[ 密度 ]:
1.29g/cm3
[ 沸点 ]:
440.9ºC at 760 mmHg
[ 分子式 ]:
C13H18ClN3O2
[ 分子量 ]:
283.75400
[ 闪点 ]:
220.5ºC
[ 精确质量 ]:
283.10900
[ PSA ]:
76.38000
[ LogP ]:
2.71350
[ 折射率 ]:
1.596
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CU9395000
- CHEMICAL NAME :
- Benzamide, 4-amino-5-chloro-2-methoxy-N-(4-piperidyl)-
- CAS REGISTRY NUMBER :
- 57645-49-5
- BEILSTEIN REFERENCE NO. :
- 0482803
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C13-H18-Cl-N3-O2
- MOLECULAR WEIGHT :
- 283.79
- WISWESSER LINE NOTATION :
- T6MTJ DMVR DZ CG FO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2550 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 25,865,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 25,865,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8750 mg/kg/5W-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Endocrine - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 25,865,1983 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3500 mg/kg
- SEX/DURATION :
- female 35 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 25,865,1983
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