L-酪氨酸-d2(苯基-2,6-d2)
L-酪氨酸-d2(苯基-2,6-d2)用途
L-酪氨酸-d2-2是氘标记的L-酪氨酸。L-酪氨酸是一种非必需氨基酸,可抑制后部皮层的柠檬酸合成酶活性。
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L-酪氨酸-d2(苯基-2,6-d2)名称
[ CAS 号 ]:
57746-15-3
[ 中文名 ]:
L-酪氨酸-d2(苯基-2,6-d2)
[ 英文名 ]:
L-(2,6-2H2)Tyrosine
[英文别名 ]:
- [2',6'-2H2]-L-tyrosine
- L-(2,6-H)Tyrosine
- L-Tyrosine-2,6-d2
- L-4-Hydroxyphenyl-2,6-d2-alanine
- L-Tyrosine-d2 (phenyl-2,6-d2)
- L-Tyrosine-2,6-d
- MFCD00190464
L-酪氨酸-d2(苯基-2,6-d2)生物活性
[ 描述 ]:
L-酪氨酸-d2-2是氘标记的L-酪氨酸。L-酪氨酸是一种非必需氨基酸,可抑制后部皮层的柠檬酸合成酶活性。
[ 相关类别 ]:
[体外研究]
氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
[参考文献]
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
[3]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
[4]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
[5]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
[6]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
[7]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
[8]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
[9]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
[10]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
[11]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
[12]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
[13]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
L-酪氨酸-d2(苯基-2,6-d2)物理化学性质
[ 密度 ]:
1.3±0.1 g/cm3
[ 沸点 ]:
385.2±32.0 °C at 760 mmHg
[ 熔点 ]:
>300ºC (dec.)(lit.)
[ 分子式 ]:
C9H9D2NO3
[ 分子量 ]:
183.201
[ 闪点 ]:
186.7±25.1 °C
[ 精确质量 ]:
183.086441
[ PSA ]:
83.55000
[ LogP ]:
0.38
[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C
[ 折射率 ]:
1.614
L-酪氨酸-d2(苯基-2,6-d2)MSDS
L-酪氨酸-d2(苯基-2,6-d2)安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H315-H319-H335
[ 警示性声明 ]:
P261-P305 + P351 + P338
[ 危害码 (欧洲) ]:
Xi
[ 风险声明 (欧洲) ]:
36/37/38
[ 安全声明 (欧洲) ]:
26-36
[ 危险品运输编码 ]:
NONH for all modes of transport
L-酪氨酸-d2(苯基-2,6-d2)合成路线
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