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2-[1-哌嗪]喹啉马来酸盐

2-[1-哌嗪]喹啉马来酸盐名称

[ CAS 号 ]:
5786-68-5

[ 中文名 ]:
2-[1-哌嗪]喹啉马来酸盐

[ 英文名 ]:
Quipazine maleate

[英文别名 ]:

(Z)-but-2-enedioic acid,2-piperazin-1-ylquinoline
EINECS 227-314-2
MFCD00133796

2-[1-哌嗪]喹啉马来酸盐物理化学性质

[ 密度 ]:
1.152g/cm3

[ 沸点 ]:
403.7ºC at 760mmHg

[ 分子式 ]:
C₁₇H₁₉N₃O₄

[ 分子量 ]:
329.35000

[ 闪点 ]:
198ºC

[ 精确质量 ]:
329.13800

[ PSA ]:
102.76000

[ LogP ]:
1.75000

[ 储存条件 ]:
2-8°C

2-[1-哌嗪]喹啉马来酸盐MSDS

详细MSDS(安全技术说明书)

2-[1-哌嗪]喹啉马来酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC2515000

CAS REGISTRY NUMBER :: 5786-68-5

LAST UPDATED :: 199206

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H15-N3.C4-H4-O4

MOLECULAR WEIGHT :: 329.39

WISWESSER LINE NOTATION :: T66 BNJ C- DT6M DNTJ &QV1U1VQ -C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle contraction or spasticity

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,530,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle contraction or spasticity

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,530,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle contraction or spasticity

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,530,1980

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2-[1-哌嗪]喹啉马来酸盐安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ RTECS号 ]:
VC2515000

2-[1-哌嗪]喹啉马来酸盐文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

Serotonergic pharmacotherapy promotes cortical reorganization after spinal cord injury.

Exp. Neurol. 241 , 84-94, (2013)

Cortical reorganization plays a significant role in recovery of function after injury of the central nervous system. The neural mechanisms that underlie this reorganization may be the same as those no...

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