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α-生育酚醋酸酯

α-生育酚醋酸酯用途

D-α-Tocopherol acetate (D-Vitamin E acetate) 可水解为 d-α-生育酚 (VE) 并被小肠吸收。

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α-生育酚醋酸酯名称

[ CAS 号 ]:
58-95-7

[ 中文名 ]:
D-alpha-生育酚醋酸酯

[ 英文名 ]:
alpha-Tocopherol acetate

[中文别名 ]:

[英文别名 ]:

a-Tocopheryl Acetate
Vitamin E acetate
EINECS 231-710-0
Eprolin
Tocopheryl acetate
E-Vimin
Evion
MFCD00072052
Vitamin- E acetate
D-α-Tocopheryl acetate

α-生育酚醋酸酯生物活性

[ 描述 ]:

D-α-Tocopherol acetate (D-Vitamin E acetate) 可水解为 d-α-生育酚 (VE) 并被小肠吸收。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. Fukui E, et al. Enhancing effect of medium-chain triglycerides on intestinal absorption of d-alpha-tocopherol acetate from lecithin-dispersed preparations in the rat. J Pharmacobiodyn. 1989 Feb;12(2):80-6.

α-生育酚醋酸酯物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
184 ºC

[ 熔点 ]:
28 ºC

[ 分子式 ]:
C₃₁H₅₂O₃

[ 分子量 ]:
472.743

[ 闪点 ]:
235.6±24.7 °C

[ 精确质量 ]:
472.391632

[ PSA ]:
35.53000

[ LogP ]:
12.07

[ 外观性状 ]:
灰白色结晶固体

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.488

[ 储存条件 ]:
存放于惰性气体之中;避免光,空气

[ 水溶解性 ]:
<0.1 g/100 mL at 17 ºC

α-生育酚醋酸酯MSDS

详细MSDS(安全技术说明书)

α-生育酚醋酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GP8280000

CHEMICAL NAME :: 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-

CAS REGISTRY NUMBER :: 58-95-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C31-H52-O3

MOLECULAR WEIGHT :: 472.83

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 182 gm/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in other cell count (unspecified)

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,1043,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80575 No. of Facilities: 149 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 8005 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80575 No. of Facilities: 834 (estimated) No. of Industries: 5 No. of Occupations: 9 No. of Employees: 8113 (estimated) No. of Female Employees: 5676 (estimated)

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α-生育酚醋酸酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
GP8280000

α-生育酚醋酸酯上下游产品

α-生育酚醋酸酯上游产品

α-生育酚醋酸酯下游产品

α-生育酚醋酸酯制备

植醇与2，3，5-三甲基对苯二酚缩合，再与醋酐在锌及醋酸钠作用下制得。

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α-生育酚醋酸酯文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Phytantriol-based in situ liquid crystals with long-term release for intra-articular administration.

AAPS PharmSciTech 16 , 846-54, (2015)

The purpose of this study was to develop an injectable in situ liquid crystal formulation for intra-articular (IA) administration, and in situ forming a viscous liquid crystalline gel with long-term r...

Microbeads: a novel multiparticulate drug delivery technology for increasing the solubility and dissolution of celecoxib.

Pharm. Dev. Technol. 20(2) , 211-8, (2015)

The purpose of this study was to develop a novel multipaticulate drug delivery technology suitable for the delivery of pre-solubilized celecoxib to the gastrointestinal tract and more specifically to ...

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α-生育酚醋酸酯

α-生育酚醋酸酯用途

α-生育酚醋酸酯名称

α-生育酚醋酸酯生物活性

α-生育酚醋酸酯物理化学性质

α-生育酚醋酸酯MSDS

详细MSDS(安全技术说明书)

α-生育酚醋酸酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

α-生育酚醋酸酯安全信息

α-生育酚醋酸酯上下游产品

α-生育酚醋酸酯上游产品

α-生育酚醋酸酯下游产品

α-生育酚醋酸酯制备

α-生育酚醋酸酯文献

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