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2-硝基萘

2-硝基萘用途

用于制造染料，及用于有机合成。

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2-硝基萘名称

[ CAS 号 ]:
581-89-5

[ 中文名 ]:
2-硝基萘

[ 英文名 ]:
2-Nitronaphthalene

[英文别名 ]:

EINECS 209-474-5
MFCD00004055
2-Nitronaphthalene
Naphthalene, 2-nitro-
β-Nitronaphthalene

2-硝基萘物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
319.6±11.0 °C at 760 mmHg

[ 熔点 ]:
65-73 °C

[ 分子式 ]:
C₁₀H₇NO₂

[ 分子量 ]:
173.168

[ 闪点 ]:
158.7±12.1 °C

[ 精确质量 ]:
173.047684

[ PSA ]:
45.82000

[ LogP ]:
3.18

[ 外观性状 ]:
黄色至棕色固体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.671

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

2-硝基萘MSDS

2-硝基萘毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ9760000

CHEMICAL NAME :: Naphthalene, 2-nitro-

CAS REGISTRY NUMBER :: 581-89-5

BEILSTEIN REFERENCE NO. :: 2046354

LAST UPDATED :: 199801

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C10-H7-N-O2

MOLECULAR WEIGHT :: 173.18

WISWESSER LINE NOTATION :: L66J CNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4400 mg/kg

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2650 mg/kg

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2400 mg/kg/34/W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 340 gm/kg/5Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

REFERENCE :: IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 19,642,1977 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,303,1989 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,303,1989 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,303,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.035 ppm (0.25 mg/m3);Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2-NITRONAPHTHALENE-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

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2-硝基萘安全信息

[ 符号 ]:

GHS02, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H228-H350-H411

[ 警示性声明 ]:
P201-P210-P273-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R45;R51/53

[ 安全声明 (欧洲) ]:
53-45-61-60

[ 危险品运输编码 ]:
2538

[ WGK德国 ]:
3

[ RTECS号 ]:
QJ9760000

[ 包装等级 ]:
III

[ 危险类别 ]:
4.1

[ 海关编码 ]:
2904209090

2-硝基萘合成路线

2-硝基萘海关

[ 海关编码 ]: 2904209090

[ 中文概述 ]:
2904209090 其他仅含硝基或亚硝基的衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2904209090 derivatives containing only nitro or only nitroso groups。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

2-硝基萘文献

Comparative cytotoxicity of naphthalene and its monomethyl- and mononitro-derivatives in the mouse lung.

J. Appl. Toxicol. 6(1) , 13-20, (1986)

Male Swiss-Webster mice were exposed to naphthalene, 1-methyl-, 2-methyl-, 1-nitro- and 2-nitronaphthalene by intraperitoneal injection of peanut oil solutions over a dose range of 0.5-3.0 mmol kg-1 b...

Induction of LacZ mutations in Muta Mouse can distinguish carcinogenic from non-carcinogenic analogues of diaminotoluenes and nitronaphthalenes.

Mutat. Res. 608(1) , 88-96, (2006)

2,4-Diaminotoluene (2,4-DAT) is a liver carcinogen in rats and mice whereas 2,6-DAT is not. Both are genotoxic in vitro. Tests for mutations in transgenic mice, unscheduled DNA synthesis (UDS), DNA da...

1-nitronaphthalene.

IARC Monogr. Eval. Carcinog. Risks Hum. 46 , 303-12, (1989)

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