4-羟基咪达唑仑
4-羟基咪达唑仑名称
[ CAS 号 ]:
59468-85-8
[ 中文名 ]:
4-羟基咪达唑仑
[ 英文名 ]:
8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol
[中文别名 ]:
[英文别名 ]:
- 4-OH-Mdz
- 4-hydroxy-MDZ
- 4-Hydroxy Midazolam
4-羟基咪达唑仑物理化学性质
[ 密度 ]:
1.44g/cm3
[ 沸点 ]:
550.6ºC at 760 mmHg
[ 熔点 ]:
186-187ºC
[ 分子式 ]:
C18H13ClFN3O
[ 分子量 ]:
341.76700
[ 闪点 ]:
286.8ºC
[ 精确质量 ]:
341.07300
[ PSA ]:
50.41000
[ LogP ]:
3.25070
[ 折射率 ]:
1.688
4-羟基咪达唑仑安全信息
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危险品运输编码 ]:
NONH for all modes of transport
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4-羟基咪达唑仑文献
Biochem. Pharmacol. 92(4) , 701-11, (2014)
The hepatic cytochrome P450 reductase null (HRN) mouse, which has no functional hepatic Cyp P450s, may represent a useful model for examining extra-hepatic P450-related oxidative metabolism. Here the ...
Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.J. Chromatogr. A. 1374 , 122-33, (2014)
The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab...
Species differences and substrate specificity of CYP3A heteroactivation by efavirenz.Xenobiotica 45(4) , 345-52, (2015)
1. The purpose of this study was to clarify species differences in the heteroactivation of CYP3A substrates by efavirenz, which is known from clinical studies to activate midazolam 1'-hydroxylation, a...
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