替诺昔康
替诺昔康用途
替诺昔康名称
[ CAS 号 ]:
59804-37-4
[ 中文名 ]:
替诺昔康
[ 英文名 ]:
Tenoxicam
[中文别名 ]:
[英文别名 ]:
- Apo-Tenoxicam
- Mobiflex
- Tenoxicam
- Tenoxicamum
- Octiveran
- Tilcotil
- Liman
- Novo-Tenoxicam
替诺昔康生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
COX-1
COX-2
[参考文献]
[相关活性小分子]
替诺昔康物理化学性质
[ 密度 ]:
1.7±0.1 g/cm3
[ 熔点 ]:
209-2130ºC
[ 分子式 ]:
C13H11N3O4S2
[ 分子量 ]:
337.374
[ 精确质量 ]:
337.019104
[ PSA ]:
136.22000
[ LogP ]:
1.52
[ 外观性状 ]:
黄色结晶粉末
[ 折射率 ]:
1.741
[ 储存条件 ]:
-20°C Freezer
[ 水溶解性 ]:
Practically insoluble in water, sparingly soluble in methylene chloride, very slightly soluble in anhydrous ethanol. It dissolves in solutions of acids and alkalis.
替诺昔康MSDS
替诺昔康毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XJ9095060
- CHEMICAL NAME :
- 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide
- CAS REGISTRY NUMBER :
- 59804-37-4
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C13-H11-N3-O4-S2
- MOLECULAR WEIGHT :
- 337.39
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 79 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 12(Suppl 5),759,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 234 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 12(Suppl 5),759,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 186 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 12(Suppl 5),759,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 297 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 12(Suppl 5),759,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 446 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 12(Suppl 5),759,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 449 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 12(Suppl 5),759,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >128 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,1030,1987
替诺昔康安全信息
[ 符号 ]:
GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301-H311-H331
[ 警示性声明 ]:
P261-P280-P301 + P310-P311
[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T:Toxic
[ 风险声明 (欧洲) ]:
R23/24/25
[ 安全声明 (欧洲) ]:
S36/37/39-S45
[ 危险品运输编码 ]:
UN 2811
[ WGK德国 ]:
2
[ RTECS号 ]:
XJ9095060
[ 海关编码 ]:
2934999090
替诺昔康合成路线
替诺昔康上下游产品
替诺昔康上游产品
替诺昔康下游产品
替诺昔康制备
3-羟基噻吩-2-甲酸甲酯经氯化为3-氯噻吩2-甲酸,用亚硫酸氢钠对氯进行亲核取代后,再甲酯化,生成3-磺基噻吩-2-甲酸甲酯(Ⅱ),氯化使磺基成为磺酰氯,再对2-甲氨基乙酸乙酯进行酰化,然后在甲醇钠作用下环合,最后和2-氨基吡啶反应生成替诺昔康。
替诺昔康海关
[ 海关编码 ]: 2934999090
[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
替诺昔康文献
Arch. Pharm. Res. 38 , 801-12, (2015)
The objective of this study was to improve the dissolution and subsequently the therapeutic efficacy of poorly water soluble BCS class-II drugs meloxicam and tenoxicam, by lipid semi solid matrix (SSM...
[Turbidimetric determination of tenoxicam using molybdophosphoric acid].Rev. Med. Chir. Soc. Med. Nat. Iasi. 114(1) , 249-54, (2010)
A turbidimetric method was developed for tenoxicam quantification using the complexing reaction with molybdophosphoric acid in hydrochloric acid medium; the complex has a maximum of absorbance at 369 ...
Effect of age on the pharmacokinetics of tenoxicam in comparison to other non-steroidal anti-inflammatory drugs (NSAIDs).Scand. J. Rheumatol. Suppl. 80 , 86-9, (1989)
Investigations have shown that elderly patients have an increased sensitivity to the effects of non-steroidal anti-inflammatory drugs (NSAIDs) with a concomitant higher frequency of side-effects. Seve...
相关化工产品/化学物质:
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区域:上海市普陀区
价格:
联系人:徐乾明
产品详情:替诺昔康
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥188.0/5g
¥618.0/25g
联系人:刘佳
产品详情:替诺昔康
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:Tenoxicam
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥789.0/1g
¥389.0/50mg
¥需询单/1g
¥需询单/1g
联系人:李先生
产品详情:Tenoxicam
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥33.9/1g
¥30.9/250mg
¥104.9/5g
¥308.9/1ml
联系人:阿拉丁
产品详情:替诺昔康
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相关化合物
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