丙环唑

丙环唑是一种广谱的三唑类杀菌剂,可抑制羊毛甾醇转化为麦角甾醇,导致真菌细胞膜破裂。丙环唑抑制酿酒酵母,但不抑制大鼠肝脏微粒体细胞色素P450(IC50s分别为0.04µM和>200µM)。丙环唑可抑制变形链球菌和匍匐茎魔芋的生长(ED50s分别为0.073µg/mL和4.6µg/mL)。丙环唑增加活性氧(ROS)的产生。

[ 描述 ]:

[ 相关类别 ]:

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
480.0±55.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₁₇Cl₂N₃O₂

[ 分子量 ]:
342.220

[ 闪点 ]:
244.1±31.5 °C

[ 精确质量 ]:
341.069794

[ PSA ]:
49.17000

[ LogP ]:
3.88

[ 外观性状 ]:
通常作为黄色液体供应

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.624

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
水溶性：不溶；水溶解度：100 mg/l   25 °C；混溶：乙醇,甲苯,丙酮

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

XZ4620000

CHEMICAL NAME :

1H-1,2,4-Triazole, 1-((2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl )methyl)-

CAS REGISTRY NUMBER :

60207-90-1

BEILSTEIN REFERENCE NO. :

0841361

LAST UPDATED :

199710

DATA ITEMS CITED :

7

MOLECULAR FORMULA :

C15-H17-Cl2-N3-O2

MOLECULAR WEIGHT :

342.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1517 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,508,1979

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>4 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,508,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

11375 mg/kg/13W-C

TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), zonal Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 12,118,1992 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

759 ug/kg

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :

BFPHA8 Bulletin of the Faculty of Pharmacy (Cairo University). (Faculty of Pharmacy, Cairo Univ., Cairo, Egypt) V.1- 1961/62- Volume(issue)/page/year: 31,459,1993 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H317-H330-H410

[ 警示性声明 ]:
P260-P280-P301 + P312 + P330-P304 + P340 + P310-P403 + P233

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;N: Dangerous for the environment;T: Toxic;F: Flammable;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36/37-S46-S60-S61-S45-S16-S7

[ 危险品运输编码 ]:
UN3082 9/PG 3

[ RTECS号 ]:
XZ4620000

[ 海关编码 ]:
2934999025

1.先将2，4-二氯苯基甲酮溴化，生成2，4-二氯苯基溴甲基酮。再将2，4-二氯苯基溴甲基酮与1，2-戊二醇在对甲苯磺酸的存在下，于甲苯溶剂中反应生成相应的缩酮。然后在二甲基甲酰胺中与1H-1，2，4-三唑反应，制得丙环唑

制备方法二

制备方法三

[ 海关编码 ]: 2934999025

[ 中文概述 ]:
2934999025 代森硫,代森环,福吗啉 ,咯菌腈等〔包括稻瘟酯,烯酰吗啉,噻菌腈,土菌灵,恶霜灵,恶霉灵〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2934999025 5,6-dihydro-3h-imidazo[2,1-c][1,2,4]dithiazole-3-thione。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Assessing the potential for algae and macrophytes to degrade crop protection products in aquatic ecosystems.

Environ. Toxicol. Chem. 30(3) , 622-31, (2011)

Rates of pesticide degradation in aquatic ecosystems often differ between those observed within laboratory studies and field trials. Under field conditions, a number of additional processes may well h...

Analysis of microRNA and gene expression profiling in triazole fungicide-treated HepG2 cell line.

Toxicology 303 , 94-8, (2013)

MicroRNA (miRNA) plays an important role in various diseases and in cellular and molecular responses to toxicants. In the present study, we investigated differential expression of miRNAs in response t...

Quantitative changes in endogenous DNA adducts correlate with conazole in vivo mutagenicity and tumorigenicity.

Mutagenesis 27(5) , 541-9, (2012)

The mouse liver tumorigenic conazole fungicides triadimefon and propiconazole have previously been shown to be in vivo mouse liver mutagens in the Big Blue™ transgenic mutation assay when administered...

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：丙环唑标准溶液

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥328.0/2ml

联系人：刘佳

产品详情：丙环唑标准溶液

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公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Propiconazole

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥308.9/250mg ￥162.9/2ml ￥617.9/250mg ￥需询单/1g

联系人：阿拉丁

产品详情：丙环唑

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公司名：中山市迪欣化工有限公司

区域：中山市三角镇

价格：
￥225.0/1000kg

联系人：陈雪萍

产品详情：丙环唑

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