三苯基膦

三苯基膦用途

1.用于有机合成，聚合引发剂，抗菌素类药物氯洁霉素的原料，有机微量分析测定磷的标准样品。

2.制钯、铱，铑，镍等络合物催化剂，Wfttig试剂，三苯膦二卤化物脱氧（Ｎ－氧化吡啶，亚硝基苯，氢过氧化物），脱硫，脱溴试剂。使a一溴代硝基化合物生成腈。与脂肪重氮化合物反应合成a_酮醛、β一酮酸脂。Beckmann重排。吡啶铃盐的脱季铵化。与溴碘、四氯(溴)化碳，N一溴化丁二烯亚胺等共用于一些合成。

3.三苯基膦是一种相当常用的还原剂，在大多数情况下，反应都是由生成三苯基膦氧化物 (一个热力学有利的反应) 驱动的。另外，三苯基膦广泛用作金属催化剂的配体。

脱氧反应三苯基膦广泛地应用于过氧化氢或内过氧化物的还原中，反应与底物有关，可生成醇、羰基化合物或环氧化物。这类反应的主要驱动力是三苯基膦与相对较弱的O-O键 (188~209 kJ/mol) 能形成较强的P=O键。例如，利用三苯基膦可以还原分解臭氧化物、选择性制备酮和醛 (式1)。

与叠氮化物的反应三苯基膦与有机叠氮化合物反应生成亚氨基膦烷 (式2)。

亚氨基膦烷是一种较活泼的亲核试剂，易与亲电试剂反应。如与醛和酮反应生成亚胺和三苯基膦氧化物。这个反应与Wittig反应相似，称作aza-Wittig反应，这个反应的驱动力也是由于三苯基氧膦的生成 (式3)。

与有机硫化物的反应室温下三苯基膦可以使环硫化合物转化为烯烃 (式4)。

脱卤反应 α-溴代酮与三苯基膦反应生成酮 (式5)。

与有机环氧化物的反应在水和丙酮溶剂中回流，三苯基膦可以使环氧化合物在叠氮化钠参与下转化为环亚胺 (式6)。

取代吡咯的制备苯胺、呋喃二酮与三苯基膦反应生成1-苯基-2,5-吡咯二酮 (式7)。

作金属催化剂的配体它作为配体与许多过渡金属组成金属催化剂，如Pd(PPh₃)₄就是一种重要的催化剂，常用于催化偶联反应的进行，是构建碳-碳键的一种重要方法，其特点是催化条件温和。例如，在Pd(PPh₃)₄和Ag₂O的共同作用下，苯硼酸与芳香卤代烃直接反应生成联苯类化合物，该反应的产率达到了90% (式8)。除了苯硼酸和卤代物以外，镁试剂、锌试剂、锡试剂、硅化合物等均可作为偶联反应的底物。

4.广泛用于医药、石化、涂料、橡胶等行业，用作催化剂、促进剂、阻燃剂，也用作分析试剂。

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三苯基膦作用

【用途一】
用于有机合成，也用作聚合引发剂、抗菌素类药物氯洁霉素等的原料
【用途二】
在农药上用于酯交换法合成有机磷中间体亚磷酸三甲酯，进而可得到敌敌畏、久效磷、磷胺等一系列有机磷杀虫剂，此外，它可用作合成橡胶和树脂的稳定剂、聚氯乙烯的抗氧剂，用作合成醇酸树脂和聚酯树脂的原料。
【用途三】
用于有机合成，聚合引发剂，抗菌素类药物氯洁霉素的原料，有机微量分析测定磷的标准样品。

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三苯基膦名称

[ CAS 号 ]:
603-35-0

[ 中文名 ]:
三苯基膦

[ 英文名 ]:
Triphenylphosphine

[中文别名 ]:

[英文别名 ]:

PP-360
Triphenyphosphine
EINECS 210-036-0
tetrakistriphenylphosphine
Trihenylphosphine
triphenyl-phosphin
Triphenylphosphine
4-16-00-00951 (Beilstein Handbook Reference)
PPh3
Triphenyl phosphine

三苯基膦物理化学性质

[ 密度 ]:
1.132

[ 沸点 ]:
360.0±11.0 °C at 760 mmHg

[ 熔点 ]:
79-81 °C(lit.)

[ 分子式 ]:
C₁₈H₁₅P

[ 分子量 ]:
262.285

[ 闪点 ]:
181.7±0.0 °C

[ 精确质量 ]:
262.091125

[ PSA ]:
13.59000

[ LogP ]:
5.69

[ 外观性状 ]:
白色粉末

[ 蒸汽密度 ]:
9 (vs air)

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.5918 (20ºC)

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents, acids.

[ 水溶解性 ]:
Insoluble

三苯基膦MSDS

三苯基膦毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ3500000

CHEMICAL NAME :: Phosphine, triphenyl-

CAS REGISTRY NUMBER :: 603-35-0

BEILSTEIN REFERENCE NO. :: 0610776

LAST UPDATED :: 199710

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C18-H15-P

MOLECULAR WEIGHT :: 262.30

WISWESSER LINE NOTATION :: RPR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1114,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1114,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0384-0014

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1135 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: AIHAM* Annual Meeting of American Industrial Hygiene Association. (Akron, OH) For publisher information, see AIHAAP. Volume(issue)/page/year: -,-,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0384-0014

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0384-0014

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0384-0014

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570648

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,313,1974

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 9 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0384-0014 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 950 mg/kg/14D-I

TOXIC EFFECTS :: Spinal Cord - other degenerative changes Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570648

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 525 mg/kg/21D-I

TOXIC EFFECTS :: Spinal Cord - demyelination Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570648

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 94500 ug/m3/6H/4W-I

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570648 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4096 No. of Facilities: 268 (estimated) No. of Industries: 13 No. of Occupations: 18 No. of Employees: 14258 (estimated) No. of Female Employees: 1373 (estimated)

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三苯基膦安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H317-H373

[ 警示性声明 ]:
P280

[ 靶器官 ]:
Nervous system

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R43;R53

[ 安全声明 (欧洲) ]:
S36/37-S60-S61-S36/37/39-S26

[ 危险品运输编码 ]:
3077

[ WGK德国 ]:
2

[ RTECS号 ]:
SZ3500000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2919900090

三苯基膦合成路线

三苯基膦上下游产品

三苯基膦上游产品

三苯基膦下游产品

三苯基膦制备

在干操的情性气体下，用34.1克（0.22摩尔》嗅代苯，5.2克(0.21克原子)镁及108毫升无水乙醚制得格氏试剂。将所得之苯基溴化镁保存在惰性气体下，搅拌并用冰浴冷却，缓缓加入(15一20分钟)6.0克(0 .044摩尔)三氯化磷和35毫升乙醚溶液。用11毫升浓盐酸和30毫升水的溶液漫慢地处理此混合物。分出乙醚层，水层用乙醚萃取。乙醚溶液合并后，.在常压的氢气下蒸馏，直至蒸馏容器内残留物的温度达285℃残渣用乙醇重结晶二次，得白色三苯嶙8.7克(76%}，熔点79.5℃。

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三苯基膦海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

三苯基膦文献

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J. Pharm. Biomed. Anal. 97 , 141-50, (2014)

Pantethine (d-bis-(N-pantothenyl-β-aminoethyl)-disulfide, PAN), the stable disulfide form of pantetheine, has beneficial effects in vascular diseases being able to decrease the hyperlipidaemia, modera...

Clay catalyzed RNA synthesis under Martian conditions: Application for Mars return samples.

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Catalysis by montmorillonites clay minerals is regarded as a feasible mechanism for the abiotic production and polymerization of key biomolecules on early Earth. We have investigated a montmorillonite...

Synthesis of folate- pegylated polyester nanoparticles encapsulating ixabepilone for targeting folate receptor overexpressing breast cancer cells.

J. Mater. Sci. Mater. Med. 26 , 275, (2015)

The aim of this study was the preparation of novel polyester nanoparticles based on folic acid (FA)-functionalized poly(ethylene glycol)-poly(propylene succinate) (PEG-PPSu) copolymer and loaded with ...

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三苯基膦

三苯基膦用途

三苯基膦作用

三苯基膦名称

三苯基膦物理化学性质

三苯基膦MSDS

详细MSDS(安全技术说明书)

三苯基膦毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

三苯基膦安全信息

三苯基膦合成路线

详细合成路线

三苯基膦上下游产品

三苯基膦上游产品

三苯基膦下游产品

三苯基膦制备

三苯基膦海关

三苯基膦文献

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