10-[2-(4-methylpiperazin-1-yl)ethyl]phenothiazine
名称
[ CAS 号 ]:
60706-43-6
[ 英文名 ]:
10-[2-(4-methylpiperazin-1-yl)ethyl]phenothiazine
[英文别名 ]:
- 10-(2-(4-Methyl-1-piperazinyl)ethyl)phenothiazine
- 10-[2-(4-Methyl-piperazino)-aethyl]-phenothiazin
- P 527
- Phenothiazine,10-(2-(4-methyl-1-piperazinyl)ethyl)
- 10-[2-(4-methyl-piperazino)-ethyl]-phenothiazine
物理化学性质
[ 密度 ]:
1.167g/cm3
[ 沸点 ]:
479.5ºC at 760 mmHg
[ 分子式 ]:
C19H23N3S
[ 分子量 ]:
325.47100
[ 闪点 ]:
243.8ºC
[ 精确质量 ]:
325.16100
[ PSA ]:
35.02000
[ LogP ]:
3.47750
[ 折射率 ]:
1.624
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SP1130000
- CHEMICAL NAME :
- Phenothiazine, 10-(2-(4-methyl-1-piperazinyl)ethyl)-
- CAS REGISTRY NUMBER :
- 60706-43-6
- BEILSTEIN REFERENCE NO. :
- 0038803
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C19-H23-N3-S
- MOLECULAR WEIGHT :
- 325.51
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B2- AT6N DNTJ D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,106,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 220 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,106,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 640 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,106,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,106,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 36 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,106,1957
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