1,1'-Pentamethylenebis[3-(2-chloroethyl)-3-nitrosourea]
名称
[ CAS 号 ]:
60784-44-3
[ 英文名 ]:
1,1'-Pentamethylenebis[3-(2-chloroethyl)-3-nitrosourea]
物理化学性质
[ 密度 ]:
1.43g/cm3
[ 分子式 ]:
C11H20Cl2N6O4
[ 分子量 ]:
371.22000
[ 精确质量 ]:
370.09200
[ PSA ]:
130.52000
[ LogP ]:
2.42910
[ 折射率 ]:
1.581
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YT9955000
- CHEMICAL NAME :
- Urea, 1,1'-pentamethylenebis(3-(2-chloroethyl)-3-nitroso-
- CAS REGISTRY NUMBER :
- 60784-44-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C11-H20-Cl2-N6-O4
- MOLECULAR WEIGHT :
- 371.27
- WISWESSER LINE NOTATION :
- ONN2GVM5MVNNO&2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema Liver - hepatitis (hepatocellular necrosis), diffuse Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Gene conversion and mitotic recombination
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 500 umol/L/16H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,45,1977
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