美索丙嗪
美索丙嗪名称
[ CAS 号 ]:
61-01-8
[ 中文名 ]:
美索丙嗪
[ 英文名 ]:
methopromazine
[英文别名 ]:
- 2-Methoxypromazine
- Methopromazinum [INN-Latin]
- Neoproma
- RP 4632
- Methoxypromazine
- Tentone
- 2-Methoxy-10-(3'-dimethylaminopropyl)phenothiazine
- Methopromazine
- Tenton
- Methopromazin
美索丙嗪物理化学性质
[ 密度 ]:
1.143g/cm3
[ 沸点 ]:
461.8ºC at 760 mmHg
[ 分子式 ]:
C18H22N2OS
[ 分子量 ]:
314.44500
[ 闪点 ]:
233.1ºC
[ 精确质量 ]:
314.14500
[ PSA ]:
41.01000
[ LogP ]:
4.31460
[ 折射率 ]:
1.603
美索丙嗪毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO7600000
- CHEMICAL NAME :
- Phenothiazine, 10-(3-(dimethylamino)propyl)-2-methoxy
- CAS REGISTRY NUMBER :
- 61-01-8
- LAST UPDATED :
- 198209
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C18-H22-N2-O-S
- MOLECULAR WEIGHT :
- 314.48
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B3N1&1 EO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 730 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 95 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 408 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 112 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960 *** REVIEWS *** TOXICOLOGY REVIEW JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For publisher information, see BJPYAJ. Volume(issue)/page/year: 106,755,1960
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