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鸭嘴花碱

鸭嘴花碱用途

Vasicine (peganine) 是一种喹唑啉类生物碱,可从Justicia adhatoda 中分离得到。Vasicine (peganine) 具有抗结核活性。

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鸭嘴花碱名称

[ CAS 号 ]:
6159-55-3

[ 中文名 ]:
骆驼蓬碱

[ 英文名 ]:
vasicine

[中文别名 ]:

[英文别名 ]:

Pyrrolo(2,1-b)quinazolin-3-ol, 1,2,3,9-tetrahydro-
1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol
peganine
Pyrrolo[2,1-b]quinazolin-3-ol, 1,2,3,9-tetrahydro-
vasicin

鸭嘴花碱生物活性

[ 描述 ]:

Vasicine (peganine) 是一种喹唑啉类生物碱,可从Justicia adhatoda 中分离得到。Vasicine (peganine) 具有抗结核活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Grange JM, et al. Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. J Ethnopharmacol. 1996 Jan;50(1):49-53.

鸭嘴花碱物理化学性质

[ 密度 ]:
1.1124

[ 沸点 ]:
373.8±52.0 °C at 760 mmHg

[ 熔点 ]:
211.5°C

[ 分子式 ]:
C₁₁H₁₂N₂O

[ 分子量 ]:
188.226

[ 闪点 ]:
179.9±30.7 °C

[ 精确质量 ]:
188.094955

[ PSA ]:
35.83000

[ LogP ]:
-1.00

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.5850

[ 储存条件 ]:
2-8℃，干燥，密闭

鸭嘴花碱MSDS

详细MSDS(安全技术说明书)

鸭嘴花碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY9454000

CHEMICAL NAME :: Pyrrolo(2,1-b)quinazolin-3-ol, 1,2,3,9-tetrahydro-

CAS REGISTRY NUMBER :: 6159-55-3

LAST UPDATED :: 199510

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C11-H10-N2-O

MOLECULAR WEIGHT :: 186.23

WISWESSER LINE NOTATION :: T C566 BN DV GN HHT&&J

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 79 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 66,680,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 79 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 22,67,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Gastrointestinal - nausea or vomiting Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 22,67,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 22,67,1959 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 150 mg/kg

SEX/DURATION :: female 56-60 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 16,1075,1978

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鸭嘴花碱安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
UN 1544

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933990090

鸭嘴花碱上下游产品

鸭嘴花碱上游产品

鸭嘴花碱下游产品

鸭嘴花碱海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

鸭嘴花碱文献

Potentiation of oxytocin evoked responses by (+) sotalol deoxysotalol and Vasicine HCl on isolated rat and rabbit uterus.

Indian J. Med. Res. 76 Suppl , 107-14, (1982)

Natural products as templates for bioactive compound libraries: part 2. Novel modifications of vasicine (peganine) core via efficient and regioselective generation of 3-lithiodeoxyvasicine and its stereoselective addition to aliphatic ketones section sign.

Nat. Prod. Res. 20(9) , 871-81, (2006)

A general procedure for direct lithiation of deoxyvasicine was developed. 3-Lithiodeoxyvasicine intermediate was found to react with various aliphatic ketones providing derivatives of 3-(hydroxyalkyl)...

Formulation and pharmacokinetic evaluation of hard gelatin capsule encapsulating lyophilized Vasa Swaras for improved stability and oral bioavailability of vasicine.

Fitoterapia 82(3) , 446-53, (2011)

The oral bioavailability of vasicine (1) was investigated in hard gelatin capsules of lyophilized Vasa Swaras (aqueous extract of Adhatoda vasica Nees.,Fam.: Acanthaceae) The rat pharmacokinetic profi...

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