< 生产厂家价格 >

4-羟基雄烯二酮醋酸酯

4-羟基雄烯二酮醋酸酯名称

[ CAS 号 ]:
61630-32-8

[ 中文名 ]:
4-羟基雄烯二酮醋酸酯

[ 英文名 ]:
4-Androsten-4-ol-3,17-dione acetate

[英文别名 ]:

4-羟基雄烯二酮醋酸酯物理化学性质

[ 密度 ]:
1.18g/cm3

[ 沸点 ]:
501.2ºC at 760 mmHg

[ 分子式 ]:
C₂₁H₂₈O₄

[ 分子量 ]:
344.44500

[ 闪点 ]:
219.2ºC

[ 精确质量 ]:
344.19900

[ PSA ]:
60.44000

[ LogP ]:
3.97820

[ 折射率 ]:
1.548

4-羟基雄烯二酮醋酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8153000

CHEMICAL NAME :: Androst-4-ene-3,17-dione, 4-hydroxy-, acetate (ester)

CAS REGISTRY NUMBER :: 61630-32-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H28-O4

MOLECULAR WEIGHT :: 344.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 300 mg/kg

SEX/DURATION :: female 2-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 18,365,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 375 mg/kg

SEX/DURATION :: female 18 day(s) pre-mating female 1-8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 18,365,1978

点击显示

4-羟基雄烯二酮醋酸酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
BV8153000

4-羟基雄烯二酮醋酸酯合成路线

详细合成路线

4-羟基雄烯二酮醋酸酯上下游产品

4-羟基雄烯二酮醋酸酯上游产品

4-羟基雄烯二酮醋酸酯下游产品

4-羟基雄烯二酮醋酸酯文献

Aromatase inhibitors and the treatment of breast cancer.

J. Steroid Biochem. 24 , 91, (1986)

Inhibition of aromatase to reduce estrogen production by peripheral and ovarian tissue could be a useful approach to treating hormone-dependent breast cancer. Several C19, 17 keto steroids have been i...

Inhibition of estrogen biosynthesis and regression of mammary tumors by aromatase inhibitors.

Adv. Exp. Med. Biol. 138 , 179-90, (1981)

Overview of recent development of aromatase inhibitors.

Cancer Res. 42(8 Suppl) , 3312s-3314s, (1982)

Since the first publication in 1973 concerning aromatase inhibitors, several effective compounds have been reported by a number of investigators. Our studies with 4-hydroxyandrostene-3,17-dione, 4-ace...

更多文献