苯胺_MSDS_用途_密度_苯胺CAS号【62-53-3】

【用途一】
是染料工业的最重要的中间体之一，也是医药、橡胶促进剂、防老剂的主要原料，还可制香料、清漆和炸药等
【用途二】
用作分析试剂，也用于染料、树脂、假漆及香料的合成
【用途三】
苯胺是生产农药的重要原料，由苯胺可衍生N-烷基苯胺、烷基苯胺、邻硝基苯胺、邻苯二胺、苯肼、环己胺等，可作为杀菌剂敌锈钠、拌种灵、甲基灭菌胺、灭菌胺、多菌灵、嘧菌灵、苯菌灵，杀虫剂三唑磷、哒嗪硫磷、喹硫磷，除草剂甲草胺、乙草胺、丁草胺、环嗪酮、咪唑喹啉酸等的中间体。
【用途四】
苯胺是重要的中间体。由苯胺生产的较重要产品达300种。世界苯胺生产厂家大约有80多个，年总生产能力已超过270万t/a，产量约230万t；主要消费领域为MDI，2000年其消费量约占苯胺总消费量的84%。我国苯胺主要消费于MDI、染料工业、橡胶助剂、医药、农药和有机中间体等方面。2000年苯胺消费量为18.5万t，产不足需，需靠进口解决。苯胺系列中间体和染料产品有：2,6-二乙基苯胺N-乙酰苯胺、对丁基苯胺、邻苯二胺、二苯胺、重氮氨基苯、4,4'-二氨基三苯基甲烷、4,4'二氨基二苯基环己基甲烷、N,N-二甲基苯胺、N-乙基苯胺、N,N-二乙基苯胺、N,N-二丙基苯胺、对乙酰胺基苯酚、对氨基苯乙酮、4,4'-二乙氨基二苯甲酮、4-（对氨基苯）丁酸、对硝基苯胺、N-亚硝基二苯胺、β-乙酰苯胺、1,4-二苯基氨基脲、2-苯基吲哚、对苯氨基苯胺、N-甲酰苯胺、N-苯甲酰苯胺、N-乙酰苯胺、2,4,6-三氯苯胺、对碘苯胺、1-苯胺-3-甲基-5-吡唑酮、对苯二酚、二环己胺、2-（N-甲基苯胺基）丙腈、3-（N-乙基苯胺基）丙腈、2-（N-乙基苯胺基）乙醇、对氨基偶氮苯、苯肼、单苯基脲、双苯基脲、对硫氰基苯胺、4,4'二苯基甲烷二异氰酸酯、多苯基多次甲基多异氰酸酯、4-氨基乙酰苯胺、N-甲基-N-（β-羟乙基）苯胺、N-甲-N（β-氯乙基）苯胺、N,N-二甲基对苯二胺、N,N,N',N'-四甲基对苯二胺、N,N-二乙基对苯二胺、4,4'-甲撑双（N,N-二乙基苯胺、苯基硫脲、二苯基硫脲、对氨基苯磺酸、4,4'二氨基二苯甲烷苯醌、N,N-二乙醇基苯胺、乙酰乙酰苯胺、对氨基酚、N-乙基苄基苯胺、N-甲基甲酰苯胺、N-甲基乙酰苯胺、对溴乙酰苯胺、双（对氨基环己基）甲烷、苯腙二苯卡巴腙、苯乙酮苯腙、苯胺-2,4-二磺酸、对氨基偶氮苯-4'磺酸、苯肼-4-磺酸、硫代乙酰苯胺、2-甲基吲哚、2,3-二甲基吲哚、N-甲基-2-苯基吲哚
【用途五】
是染料工业的最重要的中间体之一。也是医药、橡胶促进剂、防老剂的主要原料，还可制香料、清漆和炸药等，也用作溶剂。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。

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[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
184.4±0.0 °C at 760 mmHg

[ 熔点 ]:
-6.2 °C

[ 分子式 ]:
C₆H₇N

[ 分子量 ]:
93.127

[ 闪点 ]:
70.0±0.0 °C

[ 精确质量 ]:
93.057846

[ PSA ]:
26.02000

[ LogP ]:
0.94

[ 外观性状 ]:
无色液体

[ 蒸汽密度 ]:
3.22 (185 °C, vs air)

[ 蒸汽压 ]:
0.7±0.3 mmHg at 25°C

[ 折射率 ]:
1.579

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents, bases, acids, iron and iron salts, zinc, aluminium. Light sensitive. Combustible.

[ 水溶解性 ]:
36 g/L (20 ºC)

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BW6650000

CHEMICAL NAME :: Aniline

CAS REGISTRY NUMBER :: 62-53-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 105

MOLECULAR FORMULA :: C6-H7-N

MOLECULAR WEIGHT :: 93.14

WISWESSER LINE NOTATION :: ZR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 3125 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 464 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 ppm/7H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 492 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 195 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 180 ppm/8H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 254 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 820 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 2500 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 562 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 913 mg/kg/2W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Nutritional and Gross Metabolic - changes in iron Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 550 mg/kg/5D-C

TOXIC EFFECTS :: Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg/12W-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 mg/m3/22W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 87 ppm/6H/2W-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 ug/m3/24H/80D-C

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 mg/m3/24H/21D-C

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg/6D-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11 gm/kg/29W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 72800 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Blood - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4480 mg/kg

SEX/DURATION :: female 6-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

REFERENCE :: BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 39,359,1986 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 7.6 mg/m3 (2 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,99,1987 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,27,1974 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,99,1987 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,99,1987 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (19 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,13,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (19 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (19 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (19 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (19 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 2 ppm (10 mg/m3);Skin JAN 1993 OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 2 ppm (8 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 2 ppm (7.6 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 1 ppm (4 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 2 ppm (7.6 mg/m3);STEL 4 ppm (15 mg/m3);Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 2 ppm (10 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 2 ppm (8 mg/m3);Skin;Carcinogen JAN 1993 OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993 OEL-INDIA:TWA 0.2 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 1 ppm (3.8 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 5 mg/m3;STEL 20 mg/m3;Skin JAN 1993 OEL-RUSSIA:TWA 1 ppm;STEL 0.1 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 1 ppm (4 mg/m3);STEL 2 ppm (8 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (8 mg/m3);STEL 10 ppm (40 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (10 mg/m3);STEL 5 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ANILINE AND HOMOLOGS-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 06580 No. of Facilities: 1868 (estimated) No. of Industries: 25 No. of Occupations: 46 No. of Employees: 21859 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 06580 No. of Facilities: 748 (estimated) No. of Industries: 21 No. of Occupations: 39 No. of Employees: 41988 (estimated) No. of Female Employees: 14949 (estimated)

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[ 符号 ]:

GHS05, GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H317-H318-H341-H351-H372-H410

[ 警示性声明 ]:
P201-P261-P273-P280-P301 + P310 + P330

[ 靶器官 ]:
Blood

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R23/24/25;R40;R41;R43;R48/23/24/25;R50;R68

[ 安全声明 (欧洲) ]:
S26-S27-S36/37/39-S45-S46-S61-S63-S36/37

[ 危险品运输编码 ]:
UN 1547 6.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
BW6650000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2921411000

详细合成路线

苯胺上游产品

苯胺下游产品

1.老工艺生产是铁粉还原法：硝基苯用铁粉还原，反应液经中和、洗涤、蒸馏得到成品。

2.硝基苯加氢还原法：硝基苯在铜催化剂存在下，在流化床反应器中进行气相加氢还原，反应产物经冷凝、减压蒸馏得到产品。

3.硝基苯催化加氢法：通常采用的催化剂为Cu-SiO₂，该催化剂选择性好，能顺利地将硝基苯还原成苯胺，不易产生苯核上加氢。反应是在流化床反应器内进行，氢气经纯化处理后，由加热器加热到350～400℃，再进入蒸发器，同时硝基苯由高位槽进入蒸发器，与热氢气接触气化，并过热至180～223℃，混合气体从流化床底部进入，与装于流化床内的载于硅胶上的铜催化剂接触反应，生成的粗苯胺与水蒸气由床顶排出。粗苯胺经冷凝器冷却，分离，再经精馏得成品苯胺。现在苯胺的生产已实现了连续化，还原反应在常压沸腾回流条件下进行，实现了小设备大生产。精制方法：苯胺按照制备方法不同可能含有硝基苯、甲苯胺、苯、硫化物等杂质。如果苯胺溶于稀盐酸后得到无色透明的液体，则一般不含有烃类和硝基苯。精制时，将苯胺溶解于稀盐酸或稀硫酸中，如果有不溶物，则用水蒸气蒸馏除去，在残留液中加入氢氧化钠使成碱性，再次进行水蒸气蒸馏可得苯胺。将蒸出的苯胺用固体氢氧化钠干燥，加入锌粉煮沸回流后进行蒸馏。再用固体氢氧化钠干燥，然后在氮气流下减压蒸馏可得高纯度产品。也可以将苯胺转变成它的衍生物，如苯胺盐酸盐、乙酰替苯胺后，再重结晶精制。

4.将硝基苯、氯化亚铁溶液（或氯化铵溶液）以及碎铁粉加入反应釜中，不断搅拌，进行还原反应制得。或者由氢气还原硝基苯制得。

5.直接取工业苯胺为原料于氮气气氛下，经同样的精馏也可得到试剂成品。成品须贮放于密闭棕色瓶内。为制备色谱纯苯胺，可用氮气作载气，在装有Apiezon L或SE30/白色硅藻土担体固定相柱的制备气相色谱仪上注入工业苯胺，经分离收集其主峰组分，然后装入玻璃瓿瓶中密封即可。

6.硝基苯通过催化加氢还原或用铁粉还原：

生成的苯胺可与草酸反应成苯胺草酸盐，然后经提纯后用碱处理，再于氮气气氛下经精馏收集183～185℃间馏分。

7.苯酚氨化法：在酸性二氧化铝催化剂存在下，用苯酚和氨于370℃和1.6MPa压力下反应。该工艺原料易得，生产方法简单，催化剂廉价，产品质量好，并且不会产生造成空气污染的气体或大量的水。苯酚转化率大于99%，苯胺收率在96%以上。催化剂稳定性好，不必再生，又可联产二苯胺。因此，该法适用于大规模连续化生产并可根据需要联产二苯胺。但其成本受到苯酚的影响，只有在苯酚供应充足而廉价，且要求苯胺质量较高、投资较少时才采用本法。

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥58.0/500ml

联系人：刘佳

产品详情：苯胺

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥需询单/1mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁李高志

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公司名：济南创世化工有限公司

区域：济南市天桥区

价格：
￥需询单/200kg

联系人：严玲玲

产品详情：苯胺

公司名：济南世纪通达化工有限公司

区域：济南市天桥区

价格：
￥11000.0/1ton ￥21000.0/2ton

联系人：王经理

产品详情：苯胺

公司名：山东金悦源新材料有限公司

区域：济南市天桥区

价格：
￥1500.0/200kg ￥7000.0/1ton

联系人：王思兵

产品详情：苯胺

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苯胺的危害是什么？

2019-06-11 22:01:58

苯胺又称阿尼林、阿尼林油、氨基苯，分子式:C6H7N。无色油状液体。熔点-6.3℃，沸点184℃，相对密度 1.02 (20/4℃)，相对分子量93.128，加热至370℃分解。稍溶于水，易溶于乙醇、乙醚等有机溶剂。苯胺是最重要的胺类物质之一。主要用于制造染料、药物、树脂，还可以用作橡胶硫化促进剂...

苯胺的密度是多少？1ml苯胺相当于多少mol苯胺？

2019-07-17 15:24:02

苯胺的密度为1.0217。1毫升苯胺的质量是1.0217克，物质的量是：n=m/M=1.0217/93=0.01098mol。

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