异丙铂
异丙铂用途
细胞抑制剂，和顺铂为同系物。有抗肿瘤作用。
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异丙铂名称
[ CAS 号 ]:
62928-11-4
[ 中文名 ]:
异丙铂
[ 英文名 ]:
dichlorodihydroxybis(isopropylamine)platinum
[中文别名 ]:
[英文别名 ]:
- PLATINUM,DICHLORODIHYDROXYBIS(2-PROPANAMINE)
- Iproplatin
- [Pt(IV)Cl2(OH)2(NH2-i-Pr)2]
- EINECS 263-762-5
- cis,trans,cis-[Pt(isopropylamine)2(OH)2Cl2]
- 2-Propanamine,platinum complex
- JM-9
- CHID
异丙铂物理化学性质
[ 沸点 ]:
30.9ºC at 760 mmHg
[ 分子式 ]:
C6H20Cl2N2O2Pt
[ 分子量 ]:
418.21900
[ 精确质量 ]:
417.05500
[ PSA ]:
92.50000
[ LogP ]:
3.13050
异丙铂毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TP2230500
- CHEMICAL NAME :
- Platinum(IV), bis(isopropylammine)-cis-dichloro-trans-dihydroxy-
- CAS REGISTRY NUMBER :
- 62928-11-4
- LAST UPDATED :
- 199803
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C6-H20-Cl2-N2-O2-Pt
- MOLECULAR WEIGHT :
- 418.27
- WISWESSER LINE NOTATION :
- ZY1&1 2 &Q-PT-QGG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 92 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 18 mg/kg/9W-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 17500 ug/kg/5D-I
- TOXIC EFFECTS :
- Gastrointestinal - alteration in gastric secretion Gastrointestinal - other changes
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 25,27,1989
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异丙铂合成路线
异丙铂制备
二异丙胺二氯铂经双氧水氧化，引入二个羟基即得异丙铂。
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相关化合物
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