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雄烯二酮

雄烯二酮用途

【用途一】
用作甾体激素药中间体

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雄烯二酮作用

用作甾体激素药中间体，被广泛应用丁风湿性关节炎、避孕利尿和各种将感染性炎症控制等。

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雄烯二酮名称

[ CAS 号 ]:
63-05-8

[ 中文名 ]:
雄烯二酮

[ 英文名 ]:
Androstenedione

[中文别名 ]:

[英文别名 ]:

Delta-4-Androstene-3,17-Dione
Androst-4-ene-3,17-dione
D4-Androstenedione
Androstendione
MFCD00003615
Androstenedione (JAN)
EINECS 200-554-5
17-Ketotestosterone
4-Androsten-3,17-dione
δ4-androstenedione

雄烯二酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
431.4±45.0 °C at 760 mmHg

[ 熔点 ]:
170-173ºC

[ 分子式 ]:
C₁₉H₂₆O₂

[ 分子量 ]:
286.409

[ 闪点 ]:
161.1±25.7 °C

[ 精确质量 ]:
286.193268

[ PSA ]:
34.14000

[ LogP ]:
2.90

[ 外观性状 ]:
白色至灰白色固体

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.552

[ 储存条件 ]:
库房通风低温干燥

雄烯二酮MSDS

雄烯二酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8150000

CHEMICAL NAME :: Androst-4-ene-3,17-dione

CAS REGISTRY NUMBER :: 63-05-8

LAST UPDATED :: 199307

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C19-H26-O2

MOLECULAR WEIGHT :: 286.45

WISWESSER LINE NOTATION :: L E5 B666 FV OV MUTJ A1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg/9W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 19,977,1957 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 7 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,489,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 80 mg/kg

SEX/DURATION :: female 2-5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - other measures of fertility

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 81,1091,1967

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 20 mg/kg

SEX/DURATION :: female 5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 18,271,1959

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 20 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 18,271,1959

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 10500 ug/kg

SEX/DURATION :: male 25 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: AMTUA3 Acta Medica Turcica. (Dr. Ayhan Okcuoglu, Cocuk Hastalikari Klinigi, c/o Ankara Univ., Tip Facultesi, Cebeci, Ankara, Turkey) V.1-10/11, 1948-58; New series: V.1- 1964- Volume(issue)/page/year: 8,68,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 80 mg/kg

SEX/DURATION :: female 14-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - skin and skin appendages Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - delayed effects

REFERENCE :: JCPPAV Journal of Comparative and Physiological Psychology. (Washington, DC) V.40-96, 1947-82. Volume(issue)/page/year: 92,13,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 40 mg/kg

SEX/DURATION :: female 14-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: JCPPAV Journal of Comparative and Physiological Psychology. (Washington, DC) V.40-96, 1947-82. Volume(issue)/page/year: 92,13,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 5056 ug/kg

SEX/DURATION :: female 16 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - other measures of fertility

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 56,675,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 35 mg/kg

SEX/DURATION :: female 1-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 80,1152,1967

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 17500 ug/kg

SEX/DURATION :: female 1-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 80,1152,1967

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 70 mg/kg

SEX/DURATION :: female 1-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 80,1152,1967

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雄烯二酮安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312 + H332-H319

[ 警示性声明 ]:
P210-P261-P280-P305 + P351 + P338-P370 + P378-P403 + P235

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
22-24/25-36

[ 危险品运输编码 ]:
UN 1648 3 / PGII

[ WGK德国 ]:
3

[ RTECS号 ]:
BV8150000

[ 海关编码 ]:
29372900

雄烯二酮合成路线

雄烯二酮上下游产品

雄烯二酮上游产品

雄烯二酮下游产品

雄烯二酮制备

本品无天然产物，然而是天然甾族化合物的基础物质。可由雄烷-3,17-二酮、雄烷-3,17-二醇等合成出来。为合成雄性激素的原料。

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雄烯二酮海关

[ 海关编码 ]: 29372900

雄烯二酮文献

Analysis of anabolic androgenic steroids in urine by full-capillary sample injection combined with a sweeping CE stacking method.

Anal. Bioanal. Chem 405(6) , 1969-76, (2013)

This study describes an on-line stacking CE approach by sweeping with whole capillary sample filling for analyzing five anabolic androgenic steroids in urine samples. The five anabolic steroids for de...

Androgen synthesis in the gonadotropin-suppressed human testes can be markedly suppressed by ketoconazole.

J. Clin. Endocrinol. Metab. 98(3) , 1198-206, (2013)

The concentration of intratesticular testosterone (IT-T) required for human spermatogenesis is unknown because spermatogenesis can persist despite the markedly reduced IT-T concentrations observed wit...

Metabolism of the polycyclic musk galaxolide and its interference with endogenous and xenobiotic metabolizing enzymes in the European sea bass (Dicentrarchus labrax).

Environ. Pollut. 174 , 214-21, (2013)

This study investigates the metabolism and mode of action of galaxolide (HHCB) in the European sea bass -Dicentrarchus labrax- following a single intraperitoneal injection of 50 mg HHCB/kg body weight...

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雄烯二酮

雄烯二酮用途

雄烯二酮作用

雄烯二酮名称

雄烯二酮物理化学性质

雄烯二酮MSDS

详细MSDS(安全技术说明书)

雄烯二酮毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

雄烯二酮安全信息

雄烯二酮合成路线

详细合成路线

雄烯二酮上下游产品

雄烯二酮上游产品

雄烯二酮下游产品

雄烯二酮制备

雄烯二酮海关

雄烯二酮文献

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